Published online July 20, 2009
PEDIATRICS Vol. 124 No. 2 August 2009, pp. 743-746 (doi:10.1542/peds.2008-3318)
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SPECIAL ARTICLE

Pregabalin: A New Approach to Treatment of the Dysautonomic Crisis

Felicia B. Axelrod, MDa,b and Dena Berlin, NPa

Departments of a Pediatrics
b Neurology, New York University School of Medicine, New York, New York

Nausea and dysautonomic crises severely limit function and quality of life for a large number of individuals with familial dysautonomia. We treated a small cohort of 15 patients with familial dysautonomia who suffered frequent dysautonomic crises with pregabalin. Nausea and overt crises markedly decreased in 13 (87%) of these patients and the overall assessments of benefit were extremely favorable, suggesting that pregabalin may be a potentially useful therapeutic agent for this disorder.

Key Words: familial dysautonomia • treatment • vomiting

Abbreviations: FD—familial dysautonomia • GABA—{gamma}-amino butyric acid

Accepted Dec 4, 2008.


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Prevention of Dysautonomic Crisis
Neal D. Gittleman
Pediatrics Online, 4 Sep 2009 [Full text]