Published online May 6, 2009
PEDIATRICS Vol. 123 Supplement May 2009, pp. S215-S218 (doi:10.1542/peds.2008-2952C)
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SUPPLEMENT ARTICLE


The Pathophysiology of Respiratory Impairment in Pediatric Neuromuscular Diseases

Howard B. Panitch, MD

Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

This is a summary of the presentation on the pathophysiology of respiratory impairment in pediatric neuromuscular disorders presented as part of the program on pulmonary management of pediatric patients with neuromuscular disease at the 30th annual Carrell-Krusen Neuromuscular Symposium on February 20, 2008.

Abbreviations: NMD—neuromuscular disease • DMD—Duchenne muscular dystrophy • MIP—maximum inspiratory pressure • MEP—maximum expiratory pressure • FVC—forced vital capacity • Pdi—pressure generated by the diaphragm • Pdimax—maximal pressure generated by the diaphragm • Ti—inspiratory time • Ttot—total respiratory cycle time • TTdi—tension-time index of the diaphragm • REM—rapid eye movement • TTmus—tension-time index of all the respiratory muscles

Accepted Jan 5, 2009.


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