Published online February 16, 2009
PEDIATRICS Vol. 123 Supplement March 2009, pp. S160-S167 (doi:10.1542/peds.2008-2233F)
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SUPPLEMENT ARTICLE



Complex Interactions of Pollutant and Allergen Exposures and Their Impact on People With Asthma

Peyton A. Eggleston, MD

Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University, Baltimore, Maryland

Pediatric asthma has many causes and can manifest differently in different children and at different times. Understanding the many factors related to the development and exacerbation of asthma is complicated by the complexity of the many environmental exposures related to asthma development and morbidity. Furthermore, the same environmental exposures that may cause increased symptoms at 1 point in time may be protective when the exposure occurs earlier or at high enough levels. We know that environmental exposures such as allergens, irritants, and pollutants are quite complex in their composition; further examination of this complexity may improve our understanding of this complex and highly prevalent disease.


Key Words: asthma • allergy • pollutants

Abbreviations: DEP—diesel exhaust particle • ETS—environmental tobacco smoke • HEPA—high-efficiency particulate air • IgE—immunoglobulin E • PAMP—pathogen-associated molecular pattern • TLR—Toll-like receptor • Th—T helper


Accepted Nov 4, 2008.


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N. Lurie, H. E. Mitchell, and F. J. Malveaux
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Pediatrics, March 1, 2009; 123(Supplement_3): S211 - S214.
[Abstract] [Full Text] [PDF]