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Published online February 16, 2009
PEDIATRICS Vol. 123 Supplement March 2009, pp. S151-S159 (doi:10.1542/peds.2008-2233E)
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SUPPLEMENT ARTICLE


Gene-Environment Interactions and Airway Disease in Children

David A. Schwartz, MD, MPH

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

Asthma is the most common chronic disease of childhood in the United States, affecting nearly 6.5 million children. The prevalence and severity of childhood asthma have continued to increase over the past 2 decades, despite major advances in the recognition and treatment of this condition. Representing a heterogeneous collection of airway diseases, asthma has multiple pathologic processes resulting from the interactions of genetic susceptibility and environmental exposures. Preventing and treating airway disease in children will require new research approaches to understanding these complex interactions.

Key Words: genetic susceptibility • environmental exposure • bronchial diseases

Abbreviations: BHR—bronchial hyperresponsiveness • IL—interleukin • TLR4—Toll-like receptor 4 • IgE—immunoglobulin E

Accepted Nov 4, 2008.


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