Advertising Disclaimer
Published online March 30, 2009
PEDIATRICS Vol. 123 No. 4 April 2009, pp. 1142-1146 (doi:10.1542/peds.2008-1339)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Janér, J.
Right arrow Articles by Lassus, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Janér, J.
Right arrow Articles by Lassus, P.
Related Collections
Right arrow Premature & Newborn
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

ARTICLE

Endostatin Concentration in Cord Plasma Predicts the Development of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

Joakim Janér, MDa, Sture Andersson, MD, PhDa, Eero Kajantie, MD, PhDa,b, Patrik Lassus, MD, PhDc

a Hospital for Children and Adolescents, and Department of Neonatology
c Department of Plastic Surgery, University of Helsinki, Helsinki, Finland
b National Public Health Institute, Helsinki, Finland

INTRODUCTION. Endostatin is an antiangiogenic growth factor. Together with proangiogenic growth factors it acts to shape the developing vasculature. Dysregulation of angiogenesis is a component in the pathogenesis of bronchopulmonary dysplasia.

OBJECTIVE. Our goal was to study whether the concentration of circulating endostatin at birth is associated with the development of bronchopulmonary dysplasia in very low birth weight infants.

PATIENTS AND METHODS. Endostatin concentration was measured in cord plasma from 92 very low birth weight infants (gestational age < 32 weeks; birth weight < 1500 g) and 48 healthy term infants (gestational age > 37 weeks; birth weight > 2500 g).

RESULTS. Endostatin concentration in very low birth weight infants was lower than in healthy term infants. Within the very low birth weight group no correlation existed between endostatin concentration and gestational age or relative birth weight. Very low birth weight infants who subsequently developed bronchopulmonary dysplasia had higher cord endostatin than those who did not. Higher endostatin concentration was associated with higher odds for bronchopulmonary dysplasia. Adjusted for gestational age, the odds for bronchopulmonary dysplasia were higher.

CONCLUSIONS. Circulating endostatin in term infants was higher than in very low birth weight infants, suggesting a temporal pattern for fetal endostatin concentration. In very low birth weight infants a high concentration of circulating endostatin at birth is associated with the subsequent development of bronchopulmonary dysplasia.

Key Words: angiogenesis • bronchopulmonary dysplasia • neonatal respiratory • preterm infants

Abbreviations: VEGF-A—vascular endothelial growth factor A • BPD—bronchopulmonary dysplasia • VLBW—very low birth weight • BW—birth weight • GA—gestational age • RDS—respiratory distress syndrome • BE—base excess • OR—odds ratio • CI—confidence interval

Accepted Aug 7, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?