Published online March 2, 2009
PEDIATRICS Vol. 123 No. 3 March 2009, pp. 779-783 (doi:10.1542/peds.2007-3569)

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ARTICLE

Prevalence and Natural History of Gastroesophageal Reflux: Pediatric Prospective Survey

Angelo Campanozzi, MD^a, Gabriella Boccia, MD^b, Licia Pensabene, MD^c, Fabio Panetta, MD^d, Antonio Marseglia, MD^a, Pietro Strisciuglio, MD^c, Cristiana Barbera, MD^e, Giuseppe Magazzù, MD^d, Massimo Pettoello-Mantovani, MD^a and Annamaria Staiano, MD^b

^a Department of Pediatrics, University of Foggia, Foggia, Italy
^b Department of Pediatrics, University Federico II, Naples, Italy
^c Department of Pediatrics, University Magna Graecia, Catanzaro, Italy
^d Department of Pediatrics, University of Messina, Messina, Italy
^e Department of Pediatrics, University of Torino, Torino, Italy

OBJECTIVE. The prevalence and natural history of gastroesophageal reflux in infants have been poorly documented. The aim of this study was to evaluate the prevalence and natural history of infant regurgitation in Italian children during the first 2 years of life.

METHODS. A detailed questionnaire, according to the Rome II criteria, was completed by 59 primary care pediatricians to assess infant regurgitation in consecutive patients seen in their office over a 3-month period. A total of 2642 patients aged 0 to 12 months were prospectively enrolled during this 3-month period. Follow-up was performed at 6, 12, 18, and 24 months of age.

RESULTS. A total of 313 children (12%; 147 girls) received the diagnosis of infant regurgitation. Vomiting was present in 34 of 313 patients. Their score for the Infant Gastroesophageal Reflux Questionnaire was 8.51 ± 4.75 (mean ± SD). Follow-up visits were conducted to the end in 210 of 313 subjects. Regurgitation had disappeared in 56 of 210 infants by the first 6 months of age, in 128 by the first 12 months, in 23 at 18 months, and in 3 patients by the first 24 months. At follow-up, 1 of 210 patients had developed a gastroesophageal reflux disease with esophagitis, proven endoscopically and histologically; another patient received a diagnosis of cow milk protein intolerance. The Infant Gastroesophageal Reflux Questionnaire score reached 0 after 8.2 ± 3.9 months in breastfed infants (89 of 210) and after 9.6 ± 4.1 months in artificially fed infants.

CONCLUSIONS. We found that 12% of Italian infants satisfied the Rome II criteria for infant regurgitation. Eighty-eight percent of 210 infants who had completed a 24-month follow-up period had improved at the age of 12 months. Only 1 patient later turned out to have gastroesophageal reflux disease. Use of breast milk was associated with a shorter time necessary to reach an Infant Gastroesophageal Reflux Questionnaire score of 0.

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Key Words: GER • GERD • prevalence • epidemiology • infants

Abbreviations: GER—gastroesophageal reflux • NHS—National Health Service • GERD—gastroesophageal reflux disease • I-GERQ—Infant Gastroesophageal Reflux Questionnaire • ETS—exposure to environmental tobacco smoke

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Accepted Jun 16, 2008.

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