Published online December 1, 2008
PEDIATRICS Vol. 122 No. 6 December 2008, pp. e1225-e1230 (doi:10.1542/10.1542/peds.2008-1380)
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ARTICLE

Strengthening the Case: Prenatal Alcohol Exposure Is Associated With Increased Risk for Conduct Disorder

Elizabeth R. Disney, PhDa, William Iacono, PhDb, Matthew McGue, PhDb, Erin Tully, PhDb and Lisa Legrand, PhDb

a Chase Brexton Health Services, Baltimore, Maryland
b Department of Psychology, University of Minnesota, Minneapolis, Minnesota

OBJECTIVE. The purpose of this study was to examine the relationship between alcohol exposure in pregnancy and offspring conduct disorder symptoms in adolescence and to examine how much this increasingly known association may be mediated by maternal and paternal externalizing diagnoses, including lifetime maternal and paternal alcohol and drug abuse/dependence diagnoses as well as antisocial disorders. Few other studies have examined the contribution of these diagnoses across both parents.

METHOD. A population sample of 1252 adolescents (53.8% female; drawn from the Minnesota Twin Family Study) as well as both of their parents completed structured diagnostic interviews to generate lifetime psychiatric diagnoses; mothers were also retrospectively interviewed about alcohol and nicotine use during pregnancy. Linear regression models were used to test the effects of prenatal alcohol exposure on adolescents' conduct-disorder symptoms.

RESULTS. Prenatal exposure to alcohol was associated with higher levels of conduct-disorder symptoms in offspring, even after statistically controlling for the effects of parental externalizing disorders (illicit substance use disorders, alcohol dependence, and antisocial/behavioral disorders), prenatal nicotine exposure, monozygosity, gestational age, and birth weight.

CONCLUSIONS. Prenatal alcohol exposure contributes to increased risk for conduct disorder in offspring.

Key Words: conduct disorder • prenatal alcohol exposure • fetal alcohol effects

Abbreviations: FAS—fetal alcohol syndrome • FASD—fetal alcohol spectrum disorders • APD—antisocial personality disorder • CD—conduct disorder • MTFS—Minnesota Twin Family Study • DSM-III-R—Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised • AAB—adult antisocial behavior

Accepted Sep 2, 2008.


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