Published online August 1, 2008
PEDIATRICS Vol. 122 No. 2 August 2008, pp. 313-321 (doi:10.1542/peds.2007-2012)

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rotteveel, J. Articles by Delemarre-Van de Waal, H. A. Search for Related Content PubMed PubMed Citation Articles by Rotteveel, J. Articles by Delemarre-Van de Waal, H. A. Related Collections Premature & Newborn Social Bookmarking                         What's this?

ARTICLE

Infant and Childhood Growth Patterns, Insulin Sensitivity, and Blood Pressure in Prematurely Born Young Adults

Joost Rotteveel, MD^a,b, Mirjam M. van Weissenbruch, MD, PhD^a,b, Jos W. R. Twisk, PhD^c,d, Henriette A. Delemarre-Van de Waal, MD, PhD^a,b

^a Department of Pediatrics
^b Institute for Clinical and Experimental Neurosciences
^c Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands
^d Institute of Health Sciences, VU University, Amsterdam, Netherlands

OBJECTIVE. Preterm infants are at increased risk to develop insulin resistance and high blood pressure. The influence of growth during childhood is not well established.

METHODS. We investigated childhood growth patterns in relation to blood pressure and insulin sensitivity, measured by the hyperinsulinemic euglycemic clamp, in young adults. We compared 29 subjects born preterm appropriate for gestational age, 28 subjects born preterm small for gestational age, and 30 subjects born at term with a normal birth weight.

RESULTS. Insulin sensitivity expressed as Mi value (glucose disposal mg/kg/min (insulin levels pmol/l) x 100) was lower in infants in the POPS-AGA (18.2) and POPS-SGA (15.2) groups than in the CON group (24.7). Systolic and diastolic blood pressure (mmHg) were higher in infants in the POPS-AGA (132/72) and POPS-SGA (127/71) groups than in the CON group (118/65). The preterm-born subjects, in lowest insulin sensitivity quartile had a higher height standard deviation score at ages 1, 2, and 5 years and a higher weight SD score at ages 2, 5, 10, 19, and 21 years than did those in the lowest insulin sensitivity quartile. The infants in the highest systolic blood pressure quartile had a higher height SD score at 3 months of age and at ages 2, 5, 10, 19, and 21 years and a higher weight SD score at ages 1, 2, 5, 10, 19, and 21 years than those in the lowest systolic blood pressure quartile.

CONCLUSIONS. Young adults born preterm have lower insulin sensitivity and higher blood pressure than controls. Increments in height and weight during childhood are associated with lower insulin sensitivity and higher blood pressure in adulthood.

---

Key Words: prematurity • growth • insulin sensitivity • blood pressure

Abbreviations: SGA—small for gestational age • AGA—appropriate for gestational age • POPS—Project on Premature and Small for Gestational Age Infants • SDS—SD score • CON—control • BIA—biometrical impedance analysis

---

Accepted Dec 12, 2007.

CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. A Martos-Moreno, V. Barrios, M. Saenz de Pipaon, J. Pozo, I. Dorronsoro, M. Martinez-Biarge, J. Quero, and J. Argente Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism Eur. J. Endocrinol., September 1, 2009; 161(3): 381 - 389. [Abstract] [Full Text] [PDF]