Published online January 2, 2008
PEDIATRICS Vol. 121 Supplement January 2008, pp. S99-S100 (doi:10.1542/peds.2007-2022AA)
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Waardenburg, D.
Right arrow Articles by Joosten, K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Van Waardenburg, D.
Right arrow Articles by Joosten, K.
Related Collections
Right arrowRelated AAP Red Book topics:
Respiratory Syncytial Virus
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

COMMUNITY PEDIATRICS


A DOUBLE-BLIND RANDOMIZED, CONTROLLED TRIAL OF PROTEIN ENERGY–ENRICHED FORMULA ADMINISTERED TO CRITICALLY ILL INFANTS

Dick Van Waardenburga, Carlijn De Betuea and Koen Joostenb

a Department of Pediatrics, Maastricht University Hospital, Maastricht, Netherlands
b Department of Pediatrics, Erasmus Medical Center-Agia Sophia Children's Hospital, Rotterdam, Netherlands

ABSTRACT

INTRODUCTION: Nutritional support is an important aspect of clinical management of critically ill infants, but the nutritional requirements of these infants are not well defined.

OBJECTIVE: Our goal was to compare tolerance, nutritional, and metabolic effects of 2 different infant formulas in critically ill infants in a double-blind, randomized way.

METHODS: Eighteen ventilated infants with respiratory insufficiency caused by respiratory syncytial virus infection were included and received an energy- and protein-enriched (PE) infant formula (Infatrini [Nutricia B. V. Zoetermeer, Zoetermeer, Netherlands]; n = 8) or standard infant formula (Nutrilon 1 [Nutricia B. V. Zoetermeer]; n = 10). Daily intake and tolerance (gastric retention, diarrhea) were recorded. Resting energy expenditure, respiratory quotient, L-amino acid concentrations, and metabolic parameters were measured, and cumulative energy balance, nitrogen balance, and substrate utilization were calculated.

RESULTS: Baseline characteristics were similar in both groups. Both formulas were well tolerated with similar volumes of intake. Results from day 4 are presented in Table 1. Levels of several amino acids (His, Val, Met, Phe, Lys, and ornithine; P < .05) were significantly higher in the infants who received the PE-enriched formula.


View this table:
[in this window]
[in a new window]

  		TABLE 1. Results on Day 4 of Admission

 
CONCLUSIONS: PE-enriched infant formula was well tolerated in critically ill infants and effective in achieving higher nutritional intakes in the first days of admission. PE-enriched formula improved energy balance and plasma amino acid profile, and a trend toward increased nitrogen balance was found.

Submitted by Dick Van Waardenburg


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?