Published online January 3, 2008
PEDIATRICS Vol. 121 Supplement January 2008, pp. S63-S78 (doi:10.1542/peds.2007-1115H)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ortega-Sanchez, I. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ortega-Sanchez, I. R.
Related Collections
Right arrow Infectious Disease & Immunity
Right arrowRelated AAP Red Book topics:
Pertussis (Whooping Cough)
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

SUPPLEMENT ARTICLE



Projected Cost-effectiveness of New Vaccines for Adolescents in the United States

Ismael R. Ortega-Sanchez, PhDa, Grace M. Lee, MDb,c, R. Jake Jacobs, MSd, Lisa A. Prosser, PhDb, Noelle-Angelique Molinari, PhDa, Xinzhi Zhang, PhDe, William B. Baine, MDf, Mary M. McCauley, MTSCa, Ted Miller, PhDg for the Working Group on Leading Economic Issues for New Vaccine for Adolescents

a National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
b Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts
c Division of Infectious Diseases, Children's Hospital Boston, Boston, Massachusetts
d Capitol Outcomes Research, Inc, Alexandria, Virginia
e National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia
f Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland
g Pacific Institute for Research and Evaluation, Calverton, Maryland

BACKGROUND. Economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. However, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood.

OBJECTIVE. Our goal was to examine economic studies of adolescent vaccines and compare cost-effectiveness outcomes among studies on a particular vaccine, across adolescent vaccines, and between new adolescent vaccines versus vaccines that are recommended for young children.

METHODS. A systematic review of economic studies on immunizations for adolescents was conducted. Studies were identified by searching the Medline, Embase, and EconLit databases. Each study was reviewed for appropriateness of model design, baseline setup, sensitivity analyses, and input variables (ie, epidemiologic, clinical, cost, and quality-of-life impact). For comparison, the cost-effectiveness outcomes reported in key studies on vaccines for younger children were selected.

RESULTS. Vaccines for healthy adolescents were consistently found to be more costly than the health care or societal cost savings they produced and, in general, were less cost-effective than vaccines for younger children. Among the new vaccines, pertussis and human papillomavirus vaccines were more cost-effective than meningococcal vaccines. Including herd-immunity benefits in studies significantly improved the cost-effectiveness estimates for new vaccines. Differences in measurements or assumptions limited further comparisons.

CONCLUSION. Although using the new adolescent vaccines is unlikely to be cost-saving, vaccination programs will result in sizable health benefits.


Key Words: cost-effectiveness • adolescents • vaccines

Abbreviations: HPV—human papillomavirus • LYS—life-years saved • QALY—quality-adjusted life-year • MPV4—meningococcal polysaccharide vaccine • MCV4—meningococcal conjugate vaccine • TdaP—tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis


Accepted Aug 22, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Arch Pediatr Adolesc MedHome page
G. M. Lee and T. A. Lieu
Vaccine Financing in the United States: An Emerging Crisis
Arch Pediatr Adolesc Med, May 1, 2009; 163(5): 485 - 487.
[Full Text] [PDF]


Home page
PediatricsHome page
G. Horlick, F. E. Shaw, M. Gorji, D. B. Fishbein, and for the Working Group on Legislation, Vaccination
Delivering New Vaccines to Adolescents: The Role of School-Entry Laws
Pediatrics, January 1, 2008; 121(Supplement_1): S79 - S84.
[Abstract] [Full Text] [PDF]