Published online February 29, 2008
PEDIATRICS Vol. 121 No. 3 March 2008, pp. 633-642 (doi:10.1542/peds.2007-3364)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hersh, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hersh, J. H.
Related Collections
Right arrow Neurology & Psychiatry
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

CLINICAL REPORT

Health Supervision for Children With Neurofibromatosis

Joseph H. Hersh, MD and Committee on Genetics

Neurofibromatosis 1 is a multisystem disorder that primarily involves the skin and nervous system. Its population prevalence is 1 in 3500. The condition usually is recognized in early childhood, when cutaneous manifestations are apparent. Although neurofibromatosis 1 is associated with marked clinical variability, most affected children do well from the standpoint of their growth and development. Some features of neurofibromatosis 1 are present at birth, and others are age-related abnormalities of tissue proliferation, which necessitate periodic monitoring to address ongoing health and developmental needs and to minimize the risk of serious medical complications. This clinical report provides a review of the clinical criteria needed to establish a diagnosis, the inheritance pattern of neurofibromatosis 1, its major clinical and developmental manifestations, and guidelines for monitoring and providing intervention to maximize the growth, development, and health of an affected child.

Key Words: neurofibromatosis • neurofibromatosis 1 • cafe-au-lait spots • neurofibroma • optic glioma

Abbreviations: NF1—neurofibromatosis type 1 • NF2—neurofibromatosis type 2 • NIH—National Institutes of Health • CLS—cafe-au-lait spot • UBO—unidentified bright object


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

The following policy statement has been revised:

Health Supervision for Children With Neurofibromatosis

Pediatrics 96: 368-372.



This article has been cited by other articles:


Home page
 PediatricsHome page
D. Rea, J. F. Brandsema, D. Armstrong, P. C. Parkin, G. deVeber, D. MacGregor, W. J. Logan, and R. Askalan
Cerebral Arteriopathy in Children With Neurofibromatosis Type 1
Pediatrics, September 1, 2009; 124(3): e476 - e483.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
K. S. Nunley, F. Gao, A. C. Albers, S. J. Bayliss, and D. H. Gutmann
Predictive Value of Cafe au Lait Macules at Initial Consultation in the Diagnosis of Neurofibromatosis Type 1
Arch Dermatol, August 1, 2009; 145(8): 883 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Emerg. Med. J.Home page
M Buckley, S Kuan, and D Barton
An unusual cause of collapse and neck pain
Emerg. Med. J., December 1, 2008; 25(12): 857 - 858.
[Abstract] [Full Text] [PDF]

Home page
 AAP NewsHome page
J. H. Hersh
Neurofibromatosis I * Report advises on examination, anticipatory guidance by age group
AAP News, March 1, 2008; 29(3): 10 - 10.
[Full Text] [PDF]