Published online November 1, 2007
PEDIATRICS Vol. 120 No. 5 November 2007, pp. e1345-e1349 (doi:10.1542/peds.2004-1681)
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EXPERIENCE & REASON

Severe Varicella Caused by Varicella-Vaccine Strain in a Child With Significant T-Cell Dysfunction

Patrick Jean-Philippe, MDa,b, Abigail Freedman, MDa,b, Mary Wu Chang, MDa,c, Sharon P. Steinbergd, Anne A. Gershon, MDd, Philip S. LaRussa, MDd and William Borkowsky, MDa,b

a Department of Pediatrics
b Saul Krugman Division of Infectious Diseases and Immunology
c Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York
d Division of Infectious Diseases, Department of Pediatrics, Columbia University Medical Center, New York, New York

ABSTRACT

In March 1995, the US Food and Drug Administration approved a live attenuated varicella vaccine for use in healthy children 12 months to 12 years old. We report here an 18-month-old girl with cell-mediated immunodeficiency who developed a severe vaccine-associated rash and clinical evidence of vaccine-associated pneumonia 1 month after inadvertent receipt of varicella vaccine.

Key Words: varicella • vaccine adverse reaction • immunodeficiency

Abbreviations: LAVV, live attenuated varicella vaccine • Ig, immunoglobulin • PCR, polymerase chain reaction • VZV, varicella-zoster virus • WT, wild type

Accepted Apr 23, 2007.