Published online November 1, 2007
PEDIATRICS Vol. 120 No. 5 November 2007, pp. 946-949 (doi:10.1542/peds.2007-1146)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khoshoo, V.
Right arrow Articles by Rubin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khoshoo, V.
Right arrow Articles by Rubin, M.
Related Collections
Right arrow Gastrointestinal Tract
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

ARTICLE

Are We Overprescribing Antireflux Medications for Infants With Regurgitation?

Vikram Khoshoo, MD, PhD, Dean Edell, MD, MPH, Aaron Thompson, MD and Mitchell Rubin, MD

Pediatric Specialty Center, West Jefferson Medical Center, New Orleans, Louisiana

OBJECTIVE. Our goal was to evaluate the diagnosis and treatment of infants with persistent regurgitation who were referred to a pediatric gastroenterology service.

METHODS. The records of 64 infants with persistent regurgitation and without any neurodevelopmental abnormalities, underlying illness, or cigarette smoke exposure were evaluated for diagnostic workup and treatment. Forty-four infants underwent extended esophageal pH monitoring.

RESULTS. Only 8 of 44 pH studies showed abnormal acid reflux. Forty-two of these 44 infants were already on antireflux medications. Other etiologies included hypertrophic pyloric stenosis (4) and renal tubular acidosis (1). Discontinuation of medication did not result in worsening of symptoms in most infants with normal pH studies.

CONCLUSIONS. The majority of infants who were prescribed antireflux drugs did not meet diagnostic criteria for gastroesophageal reflux disease.

Key Words: gastroesophageal reflux • infant

Abbreviations: GERD—gastroesophageal reflux disease

Accepted May 24, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 EDUCATION AND PRACTICEHome page
C J Kistin and H Bauchner
A picture is worth a thousand words
Arch. Dis. Child. Ed. Pract., December 1, 2008; 93(6): 177 - 189.
[Full Text] [PDF]

Home page
 Arch SurgHome page
S. L. Lee, R. M. Sydorak, V. Y. Chiu, J.-W. Hsu, H. Applebaum, and P. I. Haigh
Long-term Antireflux Medication Use Following Pediatric Nissen Fundoplication
Arch Surg, September 1, 2008; 143(9): 873 - 876.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
F. Savino and E. Castagno
Overprescription of Antireflux Medications for Infants With Regurgitation
Pediatrics, May 1, 2008; 121(5): 1070 - 1070.
[Full Text] [PDF]

Home page
 PediatricsHome page
V. Khoshoo and D. Edell
Overprescription of Antireflux Medications for Infants With Regurgitation: In Reply
Pediatrics, May 1, 2008; 121(5): 1070 - 1071.
[Full Text] [PDF]

eLetters:

Read all eLetters

Gastric acid suppression as treatment for GERD is not a benign intervention
Mathew George
Pediatrics Online, 2 Dec 2007 [Full text]