Published online November 1, 2007
PEDIATRICS Vol. 120 No. 5 November 2007, pp. 946-949 (doi:10.1542/peds.2007-1146)
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ARTICLE

Are We Overprescribing Antireflux Medications for Infants With Regurgitation?

Vikram Khoshoo, MD, PhD, Dean Edell, MD, MPH, Aaron Thompson, MD and Mitchell Rubin, MD

Pediatric Specialty Center, West Jefferson Medical Center, New Orleans, Louisiana

OBJECTIVE. Our goal was to evaluate the diagnosis and treatment of infants with persistent regurgitation who were referred to a pediatric gastroenterology service.

METHODS. The records of 64 infants with persistent regurgitation and without any neurodevelopmental abnormalities, underlying illness, or cigarette smoke exposure were evaluated for diagnostic workup and treatment. Forty-four infants underwent extended esophageal pH monitoring.

RESULTS. Only 8 of 44 pH studies showed abnormal acid reflux. Forty-two of these 44 infants were already on antireflux medications. Other etiologies included hypertrophic pyloric stenosis (4) and renal tubular acidosis (1). Discontinuation of medication did not result in worsening of symptoms in most infants with normal pH studies.

CONCLUSIONS. The majority of infants who were prescribed antireflux drugs did not meet diagnostic criteria for gastroesophageal reflux disease.

Key Words: gastroesophageal reflux • infant

Abbreviations: GERD—gastroesophageal reflux disease

Accepted May 24, 2007.




This article has been cited by other articles:


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F. Savino and E. Castagno
Overprescription of Antireflux Medications for Infants With Regurgitation
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 PediatricsHome page
V. Khoshoo and D. Edell
Overprescription of Antireflux Medications for Infants With Regurgitation: In Reply
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P3Rs:

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Gastric acid suppression as treatment for GERD is not a benign intervention
Mathew George
Pediatrics Online, 2 Dec 2007 [Full text]