Published online September 24, 2007
PEDIATRICS Vol. 120 No. 4 October 2007, pp. e1120-e1122 (doi:10.1542/peds.2006-3397)
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EXPERIENCE & REASON

Correction of Celiac Disease After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia

Ronald M. Kline, MDa,b,c, Steven M.L. Neudorf, MDd,e and Howard I. Baron, MDb,f

a Pediatric Division, Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
b Department of Pediatrics, University of Nevada School of Medicine, Las Vegas, Nevada
c Department of Clinical Education, Touro University Nevada College of Osteopathic Medicine, Henderson, Nevada
d Division of Oncology, Children's Hospital of Orange County, Orange, California
e Department of Pediatrics, University of California-Irvine, Irvine, California
f Pediatric Gastroenterology and Nutrition Associates, Las Vegas, Nevada

ABSTRACT

Allogeneic hematopoietic stem cell transplantation has been shown to correct or improve a variety of autoimmune disorders. This has not been reported for celiac disease, but transmission to a hematopoietic stem cell transplantation recipient from a donor with celiac disease has been reported. We report a 12-year-old girl with celiac disease who was diagnosed with acute leukemia and received an allogeneic hematopoietic stem cell transplant. Her celiac disease resolved after the hematopoietic stem cell transplant.

Key Words: celiac disease • hematopoietic stem cell transplantation • autoimmune disease

Abbreviations: CD, celiac disease • Ig, immunoglobulin • HSCT, hematopoietic stem cell transplantation • GvHD, graft-versus-host disease

Accepted Feb 6, 2007.