Published online October 1, 2007
PEDIATRICS Vol. 120 No. 4 October 2007, pp. e1002-e1008 (doi:10.1542/10.1542/peds.2007-0064)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kokki, H.
Right arrow Articles by Rautio, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kokki, H.
Right arrow Articles by Rautio, J.
Related Collections
Right arrow Therapeutics & Toxicology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

ARTICLE

Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children

Hannu Kokki, MD, PhDa,b, Elina Kumpulainen, BMa,b, Marko Lehtonen, MScc, Merja Laisalmi, MDb, Marja Heikkinen, MDd, Jouko Savolainen, PhDe and Jarkko Rautio, PhDc

a Departments of Pharmacology and Toxicology
c Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland
b Departments of Anesthesiology and Intensive Care
d Surgery, Kuopio University Hospital, Kuopio, Finland
e Oy Fennopharma Ltd, Kuopio, Finland

BACKGROUND. Ibuprofen is the most commonly used nonsteroidal, antipyretic, antiinflammatory analgesic in children. Nonsteroidal, antipyretic, antiinflammatory analgesics act in both the peripheral tissues and the central nervous system. The central nervous system penetration of ibuprofen has been described in adults but not in children.

OBJECTIVES. Our goals were to investigate the cerebrospinal fluid penetration of ibuprofen in children and evaluate the analgesic plasma concentration of ibuprofen after inguinal surgery in children.

MATERIALS AND METHODS. A total 36 healthy children (25 boys) aged 3 months to 12 years received a single intravenous injection of ibuprofen (10 mg/kg). A paired cerebrospinal fluid and blood sample was obtained 10 minutes to 8 hours after the injection. In children having inguinal surgery, a second blood sample was obtained at the time that the child first had wound pain.

RESULTS. The ibuprofen level was determined in all cerebrospinal fluid and plasma samples. Cerebrospinal fluid concentrations ranged between 15 and 541 µg/L, and the highest concentrations were measured 30 to 38 minutes after dosing. In all cerebrospinal fluid samples collected after 30 minutes, ibuprofen concentration exceeded that of unbound plasma. The plasma analgesic concentrations after inguinal surgery ranged between 10 and 25 mg/L.

CONCLUSIONS. Ibuprofen penetrates the cerebrospinal fluid readily, with peak concentrations attained 30 to 40 minutes after intravenous injection of a 10 mg/kg dose. The plasma analgesic concentration after inguinal surgery with spinal anesthesia is 10 to 25 mg/L.

Key Words: ibuprofen • cerebrospinal fluid • pharmacology • pharmacokinetics • analgesic concentration • child • infant

Abbreviations: NSAID—nonsteroidal antiinflammatory drug • CNS—central nervous system • PGE2— prostaglandin E2 • CSF—cerebrospinal fluid • PACU—postanesthesia care unit • BCSFB—blood-cerebrospinal fluid barrier

Accepted Mar 14, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J Clin PharmacolHome page
E. Kumpulainen, H. Kokki, M. Laisalmi, M. Heikkinen, J. Savolainen, J. Rautio, and M. Lehtonen
How Readily Does Ketorolac Penetrate Cerebrospinal Fluid in Children?
J. Clin. Pharmacol., April 1, 2008; 48(4): 495 - 501.
[Abstract] [Full Text] [PDF]