Published online August 31, 2007
PEDIATRICS Vol. 120 No. 3 September 2007, pp. 609-616 (doi:10.1542/peds.2007-0336)
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SPECIAL ARTICLE

Ischemic Perinatal Stroke: Summary of a Workshop Sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke

Tonse N.K. Raju, MD, DCHa, Karin B. Nelson, MDb, Donna Ferriero, MDc, John Kylan Lynch, DO, MPHb and the NICHD-NINDS Perinatal Stroke Workshop Participants

a National Institute of Child Health and Human Development
b National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
c Departments of Neurology and Pediatrics, University of California, San Francisco, California

Ischemic perinatal stroke is a disorder associated with significant long-term neurologic morbidity. With an estimated incidence of 1 in 2300 to 5000 births, stroke is more likely to occur in the perinatal period than at any time in childhood. The incidence of ischemic perinatal stroke ranks second only to that of strokes in the elderly population. Although ischemic perinatal stroke is a well-recognized disorder, many aspects remain to be studied. There is no consensus on its terminology, definition, or classification. Several risk factors have been identified, but their precise roles in causing stroke are not well understood. There are no reliable predictors of ischemic perinatal stroke on which to base prevention or treatment strategies. To review these important issues and propose a research agenda, the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke convened a workshop in August 2006. This article provides a summary of the workshop.

Key Words: cerebral palsy • diseases of pregnancy • focal cerebral infarction • congenital hemiplegia • hypoxic ischemic encephalopathy • intracranial hemorrhage • newborn • porencephaly • seizures • thrombotic disorders

Abbreviations: IPS—ischemic perinatal stroke • CP—cerebral palsy • MCA—middle cerebral artery • NICHD—National Institute of Child Health and Human Development • NINDS—National Institute of Neurological Disorders and Stroke • PPIS—presumed perinatal ischemic stroke • CT—computed tomography • DWI—diffusion-weighted imaging

Accepted Apr 11, 2007.




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