SPECIAL ARTICLE |
a National Institute of Child Health and Human Development
b National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
c Departments of Neurology and Pediatrics, University of California, San Francisco, California
Ischemic perinatal stroke is a disorder associated with significant long-term neurologic morbidity. With an estimated incidence of 1 in 2300 to 5000 births, stroke is more likely to occur in the perinatal period than at any time in childhood. The incidence of ischemic perinatal stroke ranks second only to that of strokes in the elderly population. Although ischemic perinatal stroke is a well-recognized disorder, many aspects remain to be studied. There is no consensus on its terminology, definition, or classification. Several risk factors have been identified, but their precise roles in causing stroke are not well understood. There are no reliable predictors of ischemic perinatal stroke on which to base prevention or treatment strategies. To review these important issues and propose a research agenda, the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke convened a workshop in August 2006. This article provides a summary of the workshop.
Key Words: cerebral palsy diseases of pregnancy focal cerebral infarction congenital hemiplegia hypoxic ischemic encephalopathy intracranial hemorrhage newborn porencephaly seizures thrombotic disorders
Abbreviations: IPS—ischemic perinatal stroke CP—cerebral palsy MCA—middle cerebral artery NICHD—National Institute of Child Health and Human Development NINDS—National Institute of Neurological Disorders and Stroke PPIS—presumed perinatal ischemic stroke CT—computed tomography DWI—diffusion-weighted imaging
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