Published online March 1, 2007
PEDIATRICS Vol. 119 Supplement March 2007, pp. S141-S144 (doi:10.1542/peds.2006-2023F)
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SUPPLEMENT ARTICLE


Calcium and Vitamin D: What Is Known About the Effects on Growing Bone

Marie B. Demay, MDa, Yves Sabbagh, PhDa and Thomas O. Carpenter, MDb

a Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
b Department of Pediatrics, Yale University, New Haven, Connecticut

The objective of these investigations was to determine if the receptor-dependent effects of 1,25-dihydroxyvitamin D were essential for normal skeletal growth. Mice with targeted ablation of the vitamin D receptor were engineered, and the skeletal consequences of vitamin D receptor ablation were studied in the presence of normal and abnormal mineral ion homeostasis. Prevention of abnormal mineral ion homeostasis resulted in the development of a normal skeleton in the absence of a functional vitamin D receptor. The metabolic cause of rickets was found to be hypophosphatemia. The major receptor-dependent actions of 1,25-dihydroxyvitamin D on skeletal development are indirect and are a reflection of the role of this hormone on intestinal calcium absorption.

Key Words: vitamin D receptor • ablation • hypophosphatemia • rickets

Abbreviations: VDR—vitamin D receptor • MGP—matrix gla protein

Accepted Oct 5, 2006.