Advertising Disclaimer
Published online May 28, 2007
PEDIATRICS Vol. 119 No. 6 June 2007, pp. e1371-e1383 (doi:10.1542/peds.2006-1232)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simoni, J. M.
Right arrow Articles by Rana, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simoni, J. M.
Right arrow Articles by Rana, S.
Related Collections
Right arrow Infectious Disease & Immunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

REVIEW ARTICLE

Adherence to Antiretroviral Therapy for Pediatric HIV Infection: A Qualitative Systematic Review With Recommendations for Research and Clinical Management

Jane M. Simoni, PhDa, Arianna Montgomery, MPHb, Erin Martin, MPHc, Michelle New, PhDd, Penelope A. Demas, PhDe, Sohail Rana, MD, FAAPf

a Department of Psychology, University of Washington, Seattle, Washington
b Center for HIV/AIDS/Viral Hepatitis/STD, and TB Prevention, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
c Departments of Special Immunology
d Psychology, Children's National Medical Center, Washington, DC
e AIDS Research Program, Montefiore Medical Center, Bronx, New York
f Department of Pediatrics and Child Health, Howard University, Washington, DC

Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. This review of >50 studies in the area of pediatric HIV infection revealed varying methods for assessing antiretroviral adherence with a wide range of estimates of adherence. Correlates of adherence could be grouped as those relating to the medication, the patient, and the caregiver/family, with many conflicting findings and a lack of theory guiding the research. Only 8 studies, mainly small feasibility or pilot investigations, evaluated highly active antiretroviral therapy adherence interventions in pediatric populations. We conclude with specific recommendations for assessment and clinical management of adherence and discuss directions for future research in this area.

Key Words: HIV/AIDS • adherence • compliance • interventions • pediatric

Abbreviations: HAART—highly active antiretroviral therapy • VL—HIV-1 RNA viral load • DOT—directly observed therapy • EDM—electronic drug monitoring • GT—gastrostomy tube

Accepted Nov 21, 2006.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Arch. Dis. Child.Home page
M Khan, X Song, K Williams, K Bright, A Sill, and N Rakhmanina
Evaluating adherence to medication in children and adolescents with HIV
Arch. Dis. Child., December 1, 2009; 94(12): 970 - 973.
[Abstract] [Full Text] [PDF]

Home page
 J Pediatr PsycholHome page
K. Malee, P. L. Williams, G. Montepiedra, S. Nichols, P. A. Sirois, D. Storm, J. Farley, B. Kammerer, and PACTG 219C Team
The Role of Cognitive Functioning in Medication Adherence of Children and Adolescents with HIV Infection
J. Pediatr. Psychol., March 1, 2009; 34(2): 164 - 175.
[Abstract] [Full Text] [PDF]