Published online April 2, 2007
PEDIATRICS Vol. 119 No. 4 April 2007, pp. 790-796 (doi:10.1542/peds.2006-2200)
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SPECIAL ARTICLE

Executive Summary of the Workshop on Oxygen in Neonatal Therapies: Controversies and Opportunities for Research

Rosemary D. Higgins, MDa, Eduardo Bancalari, MDb, Marian Willinger, PhDa and Tonse N.K. Raju, MDa

a Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
b Department of Pediatrics, University of Miami College of Medicine, Miami, Florida

One of the most complex areas in perinatal/neonatal medicine is the use of oxygen in neonatal therapies. To address the knowledge gaps that preclude optimal, evidence-based care in this critical field of perinatal medicine, the National Institute of Child Health and Human Development organized a workshop, Oxygen in Neonatal Therapies: Controversies and Opportunities for Research, in August 2005. The information presented at the workshop included basic and translational oxygen research; a review of completed, ongoing, and planned clinical trials; oxygen administration for neonatal resuscitation; and a review of the collaborative home infant monitoring evaluation study. This article provides a summary of the discussions, focusing on major knowledge gaps, with prioritized suggestions for studies in this area.

Key Words: bronchopulmonary dysplasia • intensive care • neonatal resuscitation • oxygen • retinopathy of prematurity • ventilation

Abbreviations: ROP—retinopathy of prematurity • CHIME—collaborative home infant monitoring evaluation • BOOST—Benefits of Oxygen Saturation Targeting Study • ROS—reactive oxygen species

Accepted Nov 28, 2006.