Published online March 1, 2007
PEDIATRICS Vol. 119 No. 3 March 2007, pp. 535-543 (doi:10.1542/peds.2006-2447)
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STATE-OF-THE-ART REVIEW ARTICLE

The Ketogenic Diet: One Decade Later

John M. Freeman, MD, Eric H. Kossoff, MD and Adam L. Hartman, MD

John M. Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland

ABSTRACT

The ketogenic diet, a high fat, adequate protein, low carbohydrate diet, has, during the past decade, had a resurgence of interest for the treatment of difficult-to-control seizures in children. This review traces its history, reviews its uses and side effects, and discusses possible alternatives and the diet’s possible mechanisms of action. Finally, this review looks toward possible future uses of the ketogenic diet for conditions other than epilepsy.

Key Words: ketogenic diet • pediatric epilepsy • mechanisms of action

Abbreviations: KD—ketogenic diet • MCT—medium-chain triglyceride • LCT—long-chain triglyceride

Accepted Oct 18, 2006.


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