Published online January 22, 2007
PEDIATRICS Vol. 119 No. 2 February 2007, pp. e474-e483 (doi:10.1542/peds.2006-1434)
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REVIEW ARTICLE

Colchicine Use in Children and Adolescents With Familial Mediterranean Fever: Literature Review and Consensus Statement

Tilmann Kallinich, MDa, Dieter Haffner, MDb, Tim Niehues, MDc, Kristina Huss, MDd, Elke Lainka, MDe, Ulrich Neudorf, MDe, Christof Schaefer, MDf, Silvia Stojanov, MDd, Christian Timmann, MDg, Rolf Keitzer, MDa, Huri Ozdogan, MDh and Seza Ozen, MDi

a Department of Pediatric Pneumology and Immunology, Charité Campus Virchow-Klinikum, Universitaetsmedizin Berlin, Berlin, Germany
b Department of Pediatrics, University Hospital Rostock, Rostock, Germany
c Department of Pediatric Oncology, Hematology and Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
d Department of Infectious Diseases and Immunology, Children's University Hospital, Munich, Germany
e Department of Pediatrics, University of Duisburg-Essen, Duisburg, Germany
f Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Berlin, Germany
g Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
h Cerrahpasa Faculty of Medicine, University of Istanbul, Cerrahpasa, Turkey
i Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

The daily application of colchicine is the standard therapy for prophylaxis of attacks and amyloid deposition in familial Mediterranean fever. However, because of many issues (eg, dosage, time of introduction, etc), no standardized treatment recommendations have been established. In this work we review the available literature on colchicine use with respect to its indication, efficacy, mode of application, and safety in children and adolescents with familial Mediterranean fever. On the basis of this analysis, a consensus statement on the application of colchicine in children and adolescents with familial Mediterranean fever was developed by caregivers from Germany, Austria, and Turkey.

Key Words: familial Mediterranean fever • colchicine • evidence-based guidelines • treatment

Abbreviations: FMF—familial Mediterranean fever • SAA—serum amyloid A • GFR—glomerular filtration rate

Accepted Sep 14, 2006.