Published online November 6, 2006
PEDIATRICS Vol. 118 No. 6 December 2006, pp. e1900-e1903 (doi:10.1542/peds.2006-0955)
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EXPERIENCE & REASON

Monozygotic Twins With Turner Syndrome Develop Slipped Capital Femoral Epiphysis on Growth Hormone Therapy

Zeina M. Nabhan, MD and Erica A. Eugster, MD

Section of Pediatric Endocrinology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana

ABSTRACT

Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has been associated with growth hormone therapy, as well as with Turner syndrome, but has never been described in twins with Turner syndrome. We report the first case of monozygotic twins with Turner syndrome with a 46,Xi(Xq) karyotype, both of whom developed slipped capital femoral epiphysis during growth hormone therapy. This report adds to existing reports of monozygotic twins with Turner syndrome and contributes to recognition of the potential clinical course in such patients. In addition, the association between slipped capital femoral epiphysis, growth hormone therapy, and Turner syndrome is emphasized.

Key Words: Turner syndrome • growth hormone therapy • slipped capital femoral epiphysis

Abbreviations: TS, Turner syndrome • SCFE, slipped capital femoral epiphysis • GH, growth hormone

Accepted Jun 19, 2006.