Published online December 1, 2006
PEDIATRICS Vol. 118 No. 6 December 2006, pp. 2552-2554 (doi:10.1542/peds.2006-2519)
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EXPERIENCE & REASON

Artifacts on Electroencephalograms May Influence the Amplitude-Integrated EEG Classification: A Qualitative Analysis in Neonatal Encephalopathy

Cornelia Franziska Hagmann, MDa, Nicola Jayne Robertson, PhD, FRCPCHa and Denis Azzopardi, MD, FRCPCHb

a Centre of Perinatal Brain Research, Institute of Women’s Health, University College London, London, United Kingdom
b Department of Paediatrics, Hammersmith Campus, Imperial College London, London, United Kingdom

ABSTRACT

This is a case report and a descriptive study demonstrating that artifacts are common during long-term recording of amplitude-integrated electroencephalograms and may lead to erroneous classification of the amplitude-integrated electroencephalogram trace. Artifacts occurred in 12% of 200 hours of recording time sampled from a representative sample of 20 infants with neonatal encephalopathy. Artifacts derived from electrical or movement interference occurred with similar frequency; both types of artifacts influenced the voltage and width of the amplitude-integrated electroencephalogram band. This is important knowledge especially if amplitude-integrated electroencephalogram is used as a selection tool for neuroprotection intervention studies.

Key Words: amplitude-integrated EEG • neonatal encephalopathy • neuroprotection

Abbreviations: EEG, electroencephalogram • aEEG, amplitude-integrated electroencephalogram • CFM, cerebral function monitor

Accepted Aug 30, 2006.