Published online October 9, 2006
PEDIATRICS Vol. 118 No. 5 November 2006, pp. e1593-e1599 (doi:10.1542/peds.2006-0708)
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EXPERIENCE & REASON

Gastrointestinal Tract Involvement in Langerhans Cell Histiocytosis: Case Report and Literature Review

Elizabeth Hait, MD, MPHa, Marilyn Liang, MDb, Barbara Degar, MDc, Jonathan Glickman, MD, PhDd and Victor L. Fox, MDa

a Divisions of Gastroenterology and Nutrition
b Dermatology
c Hematology and Oncology
d Pathology, Children's Hospital Boston, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts

ABSTRACT

Digestive tract involvement in Langerhans cell histiocytosis is exceedingly rare. We report a case of Langerhans cell histiocytosis in an otherwise thriving neonate presenting with hematochezia, anemia, and rash. We also review the few cases of Langerhans cell histiocytosis with gastrointestinal involvement reported in the English-language medical literature. Although gastrointestinal involvement can range in severity from mild to life-threatening, its presence may be indicative of multisystemic disease, and aggressive treatment should be considered.

Key Words: Langerhans cells histiocytosis • colitis

Abbreviations: LCH, Langerhans cell histiocytosis

Accepted May 26, 2006.


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