Published online November 1, 2006
PEDIATRICS Vol. 118 No. 5 November 2006, pp. 1999-2003 (doi:10.1542/peds.2006-0272)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murdoch, E. M.
Right arrow Articles by Kempley, S. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murdoch, E. M.
Right arrow Articles by Kempley, S. T.
Related Collections
Right arrow Premature & Newborn
Right arrowRelated AAP Red Book topics:
Yersinia enterocolitica and...
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

ARTICLE

Doppler Flow Velocimetry in the Superior Mesenteric Artery on the First Day of Life in Preterm Infants and the Risk of Neonatal Necrotizing Enterocolitis

Edile M. Murdoch, BM, MRCPa, Ajay K. Sinha, MD, FRCPCHb, Shanti T. Shanmugalingam, MB, MRCP, MRCPCHb, Gordon C.S. Smith, MD, PhDc and Stephen T. Kempley, MA, FRCPCHb

a Neonatal Intensive Care Unit, Addenbrooke's Hospital, Cambridge, United Kingdom
b Neonatal Intensive Care Unit, Royal London Hospital, Whitechapel, London, United Kingdom
c Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom

OBJECTIVE. The purpose of this work was to relate Doppler indices of splanchnic perfusion and vascular resistance to the risk of developing necrotizing enterocolitis.

METHODS. We conducted a prospective cohort study with analysis of Doppler flow velocity waveforms of splanchnic vessels on the first day of life. Clinical management and diagnosis of necrotizing enterocolitis were performed blind to the Doppler results in a tertiary NICU on 64 eligible preterm neonates admitted for intensive care. We measured necrotizing enterocolitis using an objective diagnostic classification.

RESULTS. When adjusted for gestational age at birth, the following indices of the Doppler flow velocity wave form in the superior mesenteric artery were significantly predictive of the risk of necrotizing enterocolitis: end-diastolic velocity, mean velocity, and pulsatility index. The association between necrotizing enterocolitis and Doppler velocimetry indicative of high vascular resistance was independent of a range of other factors and comorbidities (race, mode of delivery, umbilical arterial catheter, growth restriction, patent ductus arteriosus, jaundice, respiratory distress syndrome, mechanical ventilation, and hypotension).

CONCLUSIONS. We concluded that neonates with high resistance patterns of blood flow velocity in the superior mesenteric artery on the first day of life are at increased risk of developing necrotizing enterocolitis.

Key Words: necrotizing enterocolitis • Doppler ultrasonography • splanchnic circulation • superior mesenteric artery • premature infant

Abbreviations: NEC—necrotizing enterocolitis • SMA—superior mesenteric artery • CA—celiac axis • EDV—end-diastolic velocity • PI—pulsatility index

Accepted Jun 7, 2006.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
D. McCurnin and R. I. Clyman
Effects of a Patent Ductus Arteriosus on Postprandial Mesenteric Perfusion in Premature Baboons
Pediatrics, December 1, 2008; 122(6): e1262 - e1267.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M Chauhan, G Henderson, and W McGuire
Enteral feeding for very low birth weight infants: reducing the risk of necrotising enterocolitis
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2008; 93(2): F162 - F166.
[Abstract] [Full Text] [PDF]