Published online October 2, 2006
PEDIATRICS Vol. 118 No. 4 October 2006, pp. 1486-1492 (doi:10.1542/peds.2005-2629)
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ARTICLE

The Influence of Head Growth in Fetal Life, Infancy, and Childhood on Intelligence at the Ages of 4 and 8 Years

Catharine R. Gale, PhDa, Finbar J. O'Callaghan, PhDb, Maria Bredow, MBChBc, Christopher N. Martyn, DPhila and the Avon Longitudinal Study of Parents and Children Study Team

a Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
b Departments of Paediatric Neurology
c Community Child Health, Bristol Royal Hospital for Children, Bristol, United Kingdom

OBJECTIVE. We investigated the effects of head growth prenatally, during infancy, and during later periods of development on cognitive function at the ages of 4 and 8 years.

METHODS. We studied 633 term-born children from the Avon Longitudinal Study of Parents and Children cohort whose head circumference was measured at birth and at regular intervals thereafter. Their cognitive function was assessed with the Wechsler Preschool and Primary Scale of Intelligence at the age of 4 years and with the Wechsler Intelligence Scale for Children at the age of 8 years. Linear regression analysis was used to calculate postnatal head growth between successive time points, conditional on previous size, and to examine the relationship between head growth during different periods of development and later IQ.

RESULTS. When the influence of head growth was distinguished for different periods, only prenatal growth and growth during infancy were associated with subsequent IQ. At 4 years, after adjustment for parental characteristics, full-scale IQ increased an average of 2.41 points for each 1-SD increase in head circumference at birth and 1.97 points for each 1-SD increase in head growth during infancy, conditional on head size at birth. At 8 years, head circumference at birth was no longer associated with IQ, but head growth during infancy remained a significant predictor, with full-scale IQ increasing an average of 1.56 points for each 1-SD increase in growth.

CONCLUSION. The brain volume a child achieves by the age of 1 year helps determine later intelligence. Growth in brain volume after infancy may not compensate for poorer earlier growth.

Key Words: brain development • intelligence • growth

Abbreviations: ALSPAC—Avon Longitudinal Study of Parents and Children • SDS—SD score • CI—confidence interval

Accepted May 23, 2006.




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