Published online July 31, 2006
PEDIATRICS Vol. 118 No. 3 September 2006, pp. e907-e913 (doi:10.1542/peds.2006-0183)

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EXPERIENCE & REASON

Multiple Cutaneous Infantile Hemangiomas Associated With Hepatic Angiosarcoma: Case Report and Review of the Literature

Kristin M. Nord, MD^a, Jessica Kandel, MD^b, Jay H. Lefkowitch, MD^c, Steven J. Lobritto, MD^d,e, Kimberly D. Morel, MD^a,d, Paula E. North, MD, PhD^f and Maria C. Garzon, MD^a,d

^a Dermatology
^b Surgery
^c Pathology
^d Pediatrics
^e Medicine, Columbia University, New York, New York
^f Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin

ABSTRACT

Multiple cutaneous hemangiomas can be associated with internal hemangiomas, with the liver being the most common site. Here we report a case of a premature female neonate who presented with cardiac failure at birth and had typical-appearing infantile hemangiomas on the skin in association with vascular lesions in the liver. Her clinical presentation was felt to be consistent with cutaneous and hepatic infantile hemangiomas. After failure to respond to systemic steroids and chemotherapy, she underwent liver transplantation. Histopathologic evaluation of the liver revealed a diagnosis of type 2 infantile hepatic hemangioendothelioma (regarded as synonymous with angiosarcoma) rather than benign infantile hemangioma of the liver. Subsequent skin biopsies confirmed that her multiple cutaneous lesions were infantile hemangiomas and not metastatic angiosarcoma. We report this case and a review of the literature on pediatric angiosarcoma of the liver associated with cutaneous infantile hemangiomas.

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Key Words: hemangioma • neoplasm • liver transplantation

Abbreviations: IH, infantile hemangioma • IHHE, infantile hepatic hemangioendothelioma • CT, computed tomography • GLUT1, glucose transporter protein isoform 1 • HAS, hepatic angiosarcoma

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Accepted Mar 20, 2006.

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