Published online June 30, 2006
PEDIATRICS Vol. 118 No. 2 August 2006, pp. e506-e508 (doi:10.1542/peds.2005-2213)
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EXPERIENCE AND REASON

Topical Voriconazole Solution for Cutaneous Aspergillosis in a Pediatric Patient After Bone Marrow Transplant

Kristin C. Klein, PharmDa and R. Alexander Blackwood, MD, PhDb

a Clinical Sciences Division, University of Michigan College of Pharmacy and Health System, Ann Arbor, Michigan
b Division of Infectious Diseases, University of Michigan Medical School and Health System, Ann Arbor, Michigan

Invasive aspergillosis seems to be on the rise, especially in immunocompromised children. Historically, only systemic amphotericin B has been effective against Aspergillus. Development of newer antifungal agents, such as voriconazole and caspofungin, has improved the treatment options available for aspergillosis, although no definitive management strategy has been established. Here we describe the use of topical voriconazole combined with systemic antifungal agents for cutaneous aspergillosis in a pediatric patient after bone marrow transplant.

Key Words: topical voriconazole • cutaneous aspergillosis • pediatric bone marrow transplant

Abbreviations: BMT, bone marrow transplant • GVHD, graft-versus-host disease

Accepted Feb 28, 2006.