Published online August 1, 2006
PEDIATRICS Vol. 118 No. 2 August 2006, pp. 644-650 (doi:10.1542/peds.2005-2842)
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ARTICLE

High-Dose Inhaled Fluticasone Does Not Replace Oral Prednisolone in Children With Mild to Moderate Acute Asthma

Suzanne Schuh, MD, FRCP(C)a,b, Paul T. Dick, MDCM, MSc, FRCP(C)b,c, Derek Stephens, MScb, Marlene Hartley, RNa, Svetlana Khaikin, RNa, Lisa Rodrigues, BSca and Allan L. Coates, MD, CMb,d

a Divisions of Pediatric Emergency Medicine
c Pediatric Medicine
d Respiratory Medicine
b Department of Pediatrics and Population Health Sciences, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

BACKGROUND. Inhaled corticosteroids are not as effective as oral corticosteroids in school-aged children with severe acute asthma. It is uncertain how inhaled corticosteroids compare with oral corticosteroids in mild to moderate exacerbations.

PRIMARY OBJECTIVE. The purpose of this work was to determine whether there is a significant difference in the percentage of predicted forced expiratory volume in 1 second in children with mild to moderate acute asthma treated with either inhaled fluticasone or oral prednisolone.

METHODS. This was a randomized, double-blind controlled trial conducted between 2001 and 2004 in a tertiary care pediatric emergency department. We studied a convenience sample of 69 previously healthy children 5 to 17 years of age with acute asthma and forced expiratory volume in 1 second at 50% to 79% predicted value; 41 families refused participation. Albuterol was given in the emergency department and salmeterol was given after discharge to all patients, as well as either 2 mg of fluticasone via metered dose inhaler and valved holding chamber in the emergency department plus 500 µg twice daily via Diskus for 10 doses after discharge (fluticasone group, N = 35) or 2 mg/kg of oral prednisolone in the emergency department plus 5 daily doses of 1 mg/kg of prednisolone after discharge (prednisolone group, N = 34). We measured a priori defined absolute change in percent predicted forced expiratory volume in 1 second from baseline to 4 and 48 hours in the 2 groups.

RESULTS. At 240 minutes, the forced expiratory volume in 1 second increased by 19.1% ± 12.7% in the fluticasone group and 29.8% ± 15.5% in the prednisolone group. At 48 hours, this difference was no longer significant (estimated difference: 4.0 ± 3.4; P = .14). The relapse rates by 48 hours were 12.5% and 0% in the fluticasone group and prednisolone group, respectively.

CONCLUSION. Airway obstruction in children with mild to moderate acute asthma in the emergency department improves faster on oral than inhaled corticosteroids.

Key Words: oral/inhaled corticosteroids • metered dose inhaler • emergency department

Abbreviations: FEV1—forced expiratory volume in 1 second • ED—emergency department • %pred—percent predicted • MDI—metered dose inhaler • VHC—valved holding chamber • FG—fluticasone group • PG—prednisolone group • CI—confidence interval

Accepted Mar 20, 2006.




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