Published online May 1, 2006
PEDIATRICS Vol. 117 No. 6 June 2006, pp. e1253-1255 (doi:10.1542/peds.2005-2706)
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EXPERIENCE AND REASON

Interferon-{alpha} Treatment of Molluscum Contagiosum in a Patient With Hyperimmunoglobulin E Syndrome

Sara Sebnem Kilic, MD and Fatih Kilicbay, MD

Immunology Unit, Department of Pediatrics, Uludag University School of Medicine, Bursa, Turkey

We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-{alpha} for 6 months without any adverse effect.

Key Words: hyperimmunoglobulin E syndrome • Job's syndrome • molluscum contagiosum • interferon-{alpha}

Abbreviations: Ig, immunoglobulin • hyper-IgE, hyperimmunoglobulin E • MC, molluscum contagiosum • IFN, interferon

Accepted Nov 23, 2005.