Published online May 1, 2006
PEDIATRICS Vol. 117 No. 5 May 2006, pp. e821-e826 (doi:10.1542/10.1542/peds.2005-2234)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goodman, M. J.
Right arrow Articles by Zhou, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goodman, M. J.
Right arrow Articles by Zhou, X.
Related Collections
Right arrow Infectious Disease & Immunity
Right arrowRelated AAP Red Book topics:
Influenza
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

The Safety of Trivalent Influenza Vaccine Among Healthy Children 6 to 24 Months of Age

Michael J. Goodman, PhDa, James D. Nordin, MD, MPHa, Peter Harper, MD, MPHb, Teri DeFor, MSa and XingZhou Zhou, MSa

a HealthPartners Research Foundation, Minneapolis, Minnesota
b Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota

OBJECTIVE. The objective of this study was to assess the safety of routine trivalent influenza vaccine (TIV) administration among healthy children 6 through 23 months of age, after the Advisory Committee on Immunization Practices recommendation.

METHODS. The study was a retrospective case-control study of children receiving TIV in the first 2 seasons after the Advisory Committee on Immunization Practices recommendation. We assessed outcomes in the 42 days after vaccination in a population of 13383 children. Each case subject was matched, according to age and gender, with 3 control subjects. Hazard ratios were calculated with conditional logistic regression analysis.

RESULTS. We found no statistically significantly elevated hazard ratios for the first TIV dose. An elevated risk of pharyngitis was found for children receiving a second TIV dose. No elevated risk of seizure was found.

CONCLUSION. These results, for a population of healthy children, showed no medically significant adverse events related to TIV among children 6 to 23 months of age.

Key Words: safety • trivalent influenza vaccine • adverse events

Abbreviations: ACIP—Advisory Committee on Immunization Practices • HPMG—HealthPartners Medical Group • TIV—trivalent influenza vaccine • VSD—Vaccine Safety Datalink • VAERS—Vaccine Adverse Event Reporting System • CI—confidence interval

Accepted Nov 4, 2005.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JAMAHome page
S. J. Hambidge, J. M. Glanz, E. K. France, D. McClure, S. Xu, K. Yamasaki, L. Jackson, J. P. Mullooly, K. M. Zangwill, S. M. Marcy, et al.
Safety of Trivalent Inactivated Influenza Vaccine in Children 6 to 23 Months Old
JAMA, October 25, 2006; 296(16): 1990 - 1997.
[Abstract] [Full Text] [PDF]