Published online February 1, 2006
PEDIATRICS Vol. 117 No. 3 March 2006, pp. e590-e595 (doi:10.1542/10.1542/peds.2005-1349)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Ravin, S. S.
Right arrow Articles by Malech, H. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Ravin, S. S.
Right arrow Articles by Malech, H. L.
Related Collections
Right arrow Tumors
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

EXPERIENCE AND REASON

Sarcoidosis in Chronic Granulomatous Disease

Suk See De Ravin, MD, PhDa, Nora Naumann, MDa, Michael R. Robinson, MDb, Karyl S. Barron, MDa, David E. Kleiner, MD, PhDc, Jean Ulrick, RNa, Julia Friend, PA-Ca, Victoria L. Anderson, MSNa, Dirk Darnell, MSNa, Elizabeth M. Kang, MDa and Harry L. Malech, MDa

a National Institute of Allergy and Infectious Diseases
b National Eye Institute
c National Cancer Institute, National Institutes of Health, Bethesda, Maryland

In addition to increased susceptibility to infections in patients with chronic granulomatous disease (CGD), a higher incidence of sterile inflammatory disorders in these patients has been noted. However, sarcoidosis has not been reported previously in CGD. In this report, we describe two patients who have CGD and a disorder consistent with sarcoidosis on the basis of unequivocal clinical-radiographic presentations, their responses to treatment, and serum angiotensin-converting enzyme levels. Serum angiotensin-converting enzyme levels were measured in 26 other patients with CGD to establish an appropriate reference range. A possible relationship between CGD and sarcoidosis is discussed.

Key Words: chronic granulomatous disease • sarcoidosis • neurosarcoidosis • angiotensin-converting enzyme

Abbreviations: CGD, chronic granulomatous disease • ACE, angiotensin-converting enzyme • CT, computed tomography • ESR, erythrocyte sedimentation rate • SLE, systemic lupus erythematosus • TNF-{alpha}, tumor necrosis factor {alpha} • Th1, helper type 1 T cells

Accepted Aug 15, 2005.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
Q. Liu, L. I. Cheng, L. Yi, N. Zhu, A. Wood, C. M. Changpriroa, J. M. Ward, and S. H. Jackson
p47phox Deficiency Induces Macrophage Dysfunction Resulting in Progressive Crystalline Macrophage Pneumonia
Am. J. Pathol., January 1, 2009; 174(1): 153 - 163.
[Abstract] [Full Text] [PDF]