Published online March 1, 2006
PEDIATRICS Vol. 117 No. 3 March 2006, pp. e577-e589 (doi:10.1542/peds.2005-1429)
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REVIEW ARTICLE

Popular Ergogenic Drugs and Supplements in Young Athletes

Ryan Calfee, MD and Paul Fadale, MD

Brown University School of Medicine, Providence, Rhode Island

Ergogenic drugs are substances that are used to enhance athletic performance. These drugs include illicit substances as well as compounds that are marketed as nutritional supplements. Many such drugs have been used widely by professional and elite athletes for several decades. However, in recent years, research indicates that younger athletes are increasingly experimenting with these drugs to improve both appearance and athletic abilities. Ergogenic drugs that are commonly used by youths today include anabolic-androgenic steroids, steroid precursors (androstenedione and dehydroepiandrosterone), growth hormone, creatine, and ephedra alkaloids. Reviewing the literature to date, it is clear that children are exposed to these substances at younger ages than in years past, with use starting as early as middle school. Anabolic steroids and creatine do offer potential gains in body mass and strength but risk adverse effects to multiple organ systems. Steroid precursors, growth hormone, and ephedra alkaloids have not been proven to enhance any athletic measures, whereas they do impart many risks to their users. To combat this drug abuse, there have been recent changes in the legal status of several substances, changes in the rules of youth athletics including drug testing of high school students, and educational initiatives designed for the young athlete. This article summarizes the current literature regarding these ergogenic substances and details their use, effects, risks, and legal standing.


Key Words: adolescent health • athletes • drug abuse/use • nutritional supplements • steroids

Abbreviations: NCAA—National Collegiate Athletic Association • DHEA—dehydroepiandrosterone • FDA—Food and Drug Administration


Accepted Aug 11, 2005.




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