Published online December 28, 2005
PEDIATRICS Vol. 117 No. 3 March 2006, pp. 965-978 (doi:10.1542/10.1542/peds.2005-3038)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Related Collections
Right arrow Infectious Disease & Immunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

POLICY STATEMENT

Prevention of Pertussis Among Adolescents: Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis (Tdap) Vaccine

Committee on Infectious Diseases

The purpose of this statement is to provide the rationale and recommendations for adolescent use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines. Despite universal immunization of children with multiple doses of pediatric diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine, pertussis remains endemic with a steady increase in the number of reported cases. Two peaks in the incidence of pertussis occur in pediatric patients: infants younger than 6 months of age who are inadequately protected by the current immunization schedule and adolescents 11 through 18 years of age whose vaccine-induced immunity has waned. Significant medical and public health resources are being consumed in postexposure management of adolescent cases, contacts, and outbreaks with little beneficial effect on individuals or the epidemiology of disease. Two Tdap products were licensed in 2005 for use in people 10 through 18 years of age (Boostrix) and 11 through 64 years of age (Adacel). The American Academy of Pediatrics recommends the following:

Key Words: pertussis

Abbreviations: FDA—US Food and Drug Administration • Tdap—tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis • DTaP—pediatric diphtheria and tetanus toxoids and acellular pertussis • GMCs—geometric mean antibody concentrations • Td—adult-type tetanus and diphtheria toxoid • Lf—limit of flocculation units • DTP—diphtheria and tetanus and whole-cell pertussis • MPHBL—Massachusetts Public Health Biological Laboratory • sp—Sanofi Pasteur • ELS—entire or extensive limb swelling • VAERS—Vaccine Adverse Events Reporting System • CDC—Centers for Disease Control and Prevention • AAP—American Academy of Pediatrics • MCV4—tetravalent meningococcal conjugate vaccine • CI—confidence interval • GMT—geometric mean titer • TT—tetanus toxoid


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Red BookHome page
Pertussis (Whooping Cough)
Red Book, January 1, 2009; 2009(1): 504 - 519.
[Full Text]

Home page
 Red BookHome page
Immunization of Mothers and Infants
Red Book, January 1, 2009; 2009(1): 119 - 119.
[Full Text]

Home page
 PediatricsHome page
M. C. Shinall Jr, T. R. Peters, Y. Zhu, Q. Chen, and K. A. Poehling
Potential Impact of Acceleration of the Pertussis Vaccine Primary Series for Infants
Pediatrics, November 1, 2008; 122(5): 1021 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
Committee on Infectious Diseases
Infection Prevention and Control in Pediatric Ambulatory Settings
Pediatrics, September 1, 2007; 120(3): 650 - 665.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A J Pollard
New combination vaccines still need a boost
Arch. Dis. Child., January 1, 2007; 92(1): 1 - 2.
[Full Text] [PDF]

Home page
 AAP NewsHome page
L. K. Pickering
Update on status of licensure and recommendations for new vaccines
AAP News, April 1, 2006; 27(4): 22 - 22.
[Full Text]

Home page
 Red BookHome page
Pertussis (Whooping Cough)
Red Book, January 1, 2006; 2006(1): 498 - 520.
[Full Text]