Advertising Disclaimer
Published online February 1, 2006
PEDIATRICS Vol. 117 No. 2 February 2006, pp. 376-386 (doi:10.1542/peds.2005-0820)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Counsell, S. J.
Right arrow Articles by Rutherford, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Counsell, S. J.
Right arrow Articles by Rutherford, M. A.
Related Collections
Right arrow Radiology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Axial and Radial Diffusivity in Preterm Infants Who Have Diffuse White Matter Changes on Magnetic Resonance Imaging at Term-Equivalent Age

Serena J. Counsell, PhDa, Yuji Shen, PhDa, James P. Boardman, MRCPCHb, David J. Larkman, PhDa, Olga Kapellou, MRCPCHb, Philip Ward, BScb, Joanna M. Allsop, DCRa, Frances M. Cowan, PhDb, Joseph V. Hajnal, PhDa, A. David Edwards, F Med Scia,b, Mary A. Rutherford, FRCR MDa,b

a Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre
b Division of Paediatrics, Obstetrics and Gynaecology, Imperial College London, Hammersmith Hospital, London, United Kingdom

Objective. Diffuse excessive high signal intensity (DEHSI) is observed in the majority of preterm infants at term-equivalent age on conventional MRI, and diffusion-weighted imaging has shown that apparent diffusion coefficient values are elevated in the white matter (WM) in DEHSI. Our aim was to obtain diffusion tensor imaging on preterm infants at term-equivalent age and term control infants to test the hypothesis that radial diffusivity was significantly different in the WM in preterm infants with DEHSI compared with both preterm infants with normal-appearing WM on conventional MRI and term control infants.

Methods. Diffusion tensor imaging was obtained on 38 preterm infants at term-equivalent age and 8 term control infants. Values for axial ({lambda}1) and radial [({lambda}2 + {lambda}3)/2] diffusivity were calculated in regions of interest positioned in the central WM at the level of the centrum semiovale, frontal WM, posterior periventricular WM, occipital WM, anterior and posterior portions of the posterior limb of the internal capsule, and the genu and splenium of the corpus callosum.

Results. Radial diffusivity was elevated significantly in the posterior portion of the posterior limb of the internal capsule and the splenium of the corpus callosum, and both axial and radial diffusivity were elevated significantly in the WM at the level of the centrum semiovale, the frontal WM, the periventricular WM, and the occipital WM in preterm infants with DEHSI compared with preterm infants with normal-appearing WM and term control infants. There was no significant difference between term control infants and preterm infants with normal-appearing WM in any region studied.

Conclusions. These findings suggest that DEHSI represents an oligodendrocyte and/or axonal abnormality that is widespread throughout the cerebral WM.

Key Words: preterm • brain • diffusion tensor imaging • magnetic resonance imaging

Abbreviations: GA—gestational age • DEHSI—diffuse excessive high signal intensity • DWI—diffusion-weighted imaging • ADC—apparent diffusion coefficient • WM—white matter • DTI—diffusion tensor imaging • PLIC—posterior limb of the internal capsule • PMA—postmenstrual age • FOV—field of view • ROI—region of interest

Accepted May 31, 2005.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
S. Soria-Pastor, N. Padilla, L. Zubiaurre-Elorza, N. Ibarretxe-Bilbao, F. Botet, C. Costas-Moragas, C. Falcon, N. Bargallo, J. M. Mercader, and C. Junque
Decreased Regional Brain Volume and Cognitive Impairment in Preterm Children at Low Risk
Pediatrics, December 1, 2009; 124(6): e1161 - e1170.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
J. D. Yeatman, M. Ben-Shachar, R. Bammer, and H. M. Feldman
Using Diffusion Tensor Imaging and Fiber Tracking to Characterize Diffuse Perinatal White Matter Injury: A Case Report
J Child Neurol, July 1, 2009; 24(7): 795 - 800.
[Abstract] [PDF]

Home page
 RadiologyHome page
C. F. Hagmann, E. De Vita, A. Bainbridge, R. Gunny, A. B. Kapetanakis, W. K. Chong, E. B. Cady, D. G. Gadian, and N. J. Robertson
T2 at MR Imaging Is an Objective Quantitative Measure of Cerebral White Matter Signal Intensity Abnormality in Preterm Infants at Term-equivalent Age1
Radiology, July 1, 2009; 252(1): 209 - 217.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. Anjari, S. J. Counsell, L. Srinivasan, J. M. Allsop, J. V. Hajnal, M. A. Rutherford, and A. D. Edwards
The Association of Lung Disease With Cerebral White Matter Abnormalities in Preterm Infants
Pediatrics, July 1, 2009; 124(1): 268 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J.L.Y. Cheong, D.K. Thompson, H.X. Wang, R.W. Hunt, P.J. Anderson, T.E. Inder, and L.W. Doyle
Abnormal White Matter Signal on MR Imaging Is Related to Abnormal Tissue Microstructure
AJNR Am. J. Neuroradiol., March 1, 2009; 30(3): 623 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
W. Gao, W. Lin, Y. Chen, G. Gerig, J.K. Smith, V. Jewells, and J.H. Gilmore
Temporal and Spatial Development of Axonal Maturation and Myelination of White Matter in the Developing Brain
AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 290 - 296.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Heep, L. Scheef, J. Jankowski, M. Born, N. Zimmermann, D. Sival, A. Bos, J. Gieseke, P. Bartmann, H. Schild, et al.
Functional Magnetic Resonance Imaging of the Sensorimotor System in Preterm Infants
Pediatrics, January 1, 2009; 123(1): 294 - 300.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. J. Counsell, A. D. Edwards, A. T. M. Chew, M. Anjari, L. E. Dyet, L. Srinivasan, J. P. Boardman, J. M. Allsop, J. V. Hajnal, M. A. Rutherford, et al.
Specific relations between neurodevelopmental abilities and white matter microstructure in children born preterm
Brain, December 1, 2008; 131(12): 3201 - 3208.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Bassi, D. Ricci, A. Volzone, J. M. Allsop, L. Srinivasan, A. Pai, C. Ribes, L. A. Ramenghi, E. Mercuri, F. Mosca, et al.
Probabilistic diffusion tractography of the optic radiations and visual function in preterm infants at term equivalent age
Brain, February 1, 2008; 131(2): 573 - 582.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. T. Constable, L. R. Ment, B. R. Vohr, S. R. Kesler, R. K. Fulbright, C. Lacadie, S. Delancy, K. H. Katz, K. C. Schneider, R. J. Schafer, et al.
Prematurely Born Children Demonstrate White Matter Microstructural Differences at 12 Years of Age, Relative to Term Control Subjects: An Investigation of Group and Gender Effects
Pediatrics, February 1, 2008; 121(2): 306 - 316.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
Y. Bleyenheuft, C. B. Grandin, G. Cosnard, E. Olivier, and J.-L. Thonnard
Corticospinal Dysgenesis and Upper-Limb Deficits in Congenital Hemiplegia: A Diffusion Tensor Imaging Study
Pediatrics, December 1, 2007; 120(6): e1502 - e1511.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. P. Miller, P. S. McQuillen, S. Hamrick, D. Xu, D. V. Glidden, N. Charlton, T. Karl, A. Azakie, D. M. Ferriero, A. J. Barkovich, et al.
Abnormal Brain Development in Newborns with Congenital Heart Disease
N. Engl. J. Med., November 8, 2007; 357(19): 1928 - 1938.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
L. Srinivasan, R. Dutta, S. J. Counsell, J. M. Allsop, J. P. Boardman, M. A. Rutherford, and A. D. Edwards
Quantification of Deep Gray Matter in Preterm Infants at Term-Equivalent Age Using Manual Volumetry of 3-Tesla Magnetic Resonance Images
Pediatrics, April 1, 2007; 119(4): 759 - 765.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Skranes, T. R. Vangberg, S. Kulseng, M. S. Indredavik, K. A. I. Evensen, M. Martinussen, A. M. Dale, O. Haraldseth, and A.-M. Brubakk
Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight
Brain, March 1, 2007; 130(3): 654 - 666.
[Abstract] [Full Text] [PDF]