Published online February 1, 2006
PEDIATRICS Vol. 117 No. 2 February 2006, pp. 295-303 (doi:10.1542/peds.2005-0378)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gastiasoro-Cuesta, E.
Right arrow Articles by Valls-i-Soler, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gastiasoro-Cuesta, E.
Right arrow Articles by Valls-i-Soler, A.
Related Collections
Right arrow Premature & Newborn
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Acute and Sustained Effects of Lucinactant Versus Poractant-{alpha} on Pulmonary Gas Exchange and Mechanics in Premature Lambs With Respiratory Distress Syndrome

Elena Gastiasoro-Cuesta, MDa, Francisco J. Alvarez-Diaz, PhDa, Carmen Rey-Santano, PhDa, Arantxa Arnaiz-Renedo, PhDa, Begoña Loureiro-Gonzalez, MDb and Adolf Valls-i-Soler, MDb

a Research Unit for Experimental Neonatal Respiratory Physiology, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
b Neonatal Intensive Care Unit, Department of Pediatrics, Hospital Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain

BACKGROUND. Animal-derived, protein-containing surfactants seem to be superior to protein-free surfactants. Lucinactant, a synthetic surfactant containing a surfactant protein-B peptide analog, has been shown to be effective in animal models and phase II clinical trials. To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model.

OBJECTIVE. The objective was to compare the acute and sustained effects of lucinactant among premature lambs with respiratory distress syndrome (RDS) with the effects of a natural porcine surfactant (poractant-{alpha}).

METHODS. After 5 minutes of mechanical ventilation twin premature lambs were assigned randomly to the lucinactant group (30 mg/mL, 5.8 mL/kg) or the poractant-{alpha} group (80 mg/mL, 2.2 mL/kg). Heart rate, systemic arterial pressure, arterial pH, blood gas values, and lung mechanics were recorded for 12 hours.

RESULTS. Baseline fetal pH values were similar for the 2 groups (pH 7.27). After 5 minutes of mechanical ventilation, severe RDS developed (pH: <7.08; PaCO2: >80 mm Hg; PaO2: <40 mm Hg; dynamic compliance: <0.08 mL/cm H2O per kg). After surfactant instillation, similar improvements in gas exchange and lung mechanics were observed for the lucinactant and poractant-{alpha} groups at 1 hour (pH: 7.3 ± 0.1 vs 7.4 ± 0.1; PaCO2: 8 ± 18 mm Hg vs 40 ± 8 mm Hg; PaO2: 167 ± 52 mm Hg vs 259 ± 51 mm Hg; dynamic compliance: 0.3 ± 0.1 mL/cm H2O per kg vs 0.3 ± 0.1 mL/cm H2O per kg). The improvements in lung function were sustained, with no differences between groups. Cardiovascular profiles remained stable in both groups.

CONCLUSIONS. Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant.

Key Words: natural surfactant • synthetic surfactant • respiratory distress syndrome • premature lambs

Abbreviations: FIO2—fraction of inspired oxygen • MAP—mean airway pressure • OI—oxygenation index • PEEP—positive end-expiratory pressure • PIP—peak inspiratory pressure • RDS—respiratory distress syndrome • SP—surfactant protein

Accepted May 5, 2005.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Almlen, G. Stichtenoth, B. Linderholm, M. Haegerstrand-Bjorkman, B. Robertson, J. Johansson, and T. Curstedt
Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome
J Appl Physiol, April 1, 2008; 104(4): 1101 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
H. L. Halliday and C. P. Speer
Lucinactant versus poractant-alpha in premature lambs.
Pediatrics, June 1, 2006; 117(6): 2324 - 2325.
[Full Text] [PDF]

Home page
 PediatricsHome page
A. Valls-i-Soler, E. Gastiasoro-Cuesta, and F. J. Alvarez-Diaz
Lucinactant Versus Poractant-{alpha} in Premature Lambs: In Reply
Pediatrics, June 1, 2006; 117(6): 2325 - 2325.
[Full Text] [PDF]

eLetters:

Read all eLetters

Synthetic Surfactants
Satyan Lakshminrusimha, et al.
Pediatrics Online, 8 Mar 2006 [Full text]