Published online December 15, 2005
PEDIATRICS Vol. 117 No. 1 January 2006, pp. e129-e131 (doi:10.1542/peds.2005-0281)
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Areca-Nut Abuse and Neonatal Withdrawal Syndrome

Maria Angeles López-Vilchez, MDa,b, Veronica Seidel, MDa,b, MagÍ Farré, MD, PhDc, Oscár García-Algar, MD, PhDa,b, Simona Pichini, PhDd and Antonio Mur, MD, PhDa,b

a Neonatology Unit, Service of Pediatrics, Hospital Universitari del Mar
b Departments of Pediatrics, Gynecology, and Obstetrics and Preventive Medicine
c Pharmacology Unit, Institut Municipal d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain
d Drug Research and Evaluation Department, Istituto Superiore di Sanità, Rome, Italy

Areca-nut chewing occurs widely in South Asia and the Indian subcontinent. Here we present a case of neonatal withdrawal syndrome in an infant born to a woman who was a chronic areca-nut user. Arecoline, the principal neuroactive alkaloid in areca nuts, was found in the mother's placenta.

Key Words: areca nut • arecoline • neonatal withdrawal syndrome • addiction • pregnancy • newborn

Accepted Jul 8, 2005.