Published online December 1, 2005
PEDIATRICS Vol. 116 No. 6 December 2005, pp. 1513-1515 (doi:10.1542/peds.2005-0577)
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The Use of Tamoxifen to Improve Height Potential in Short Pubertal Boys

Nerissa C. Kreher, MD, Erica A. Eugster, MD and R. Ravi Shankar, MD

From the Section of Pediatric Endocrinology and Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana

A retrospective chart review of 7 pubertal boys who were treated with tamoxifen was conducted to determine the effects of this therapy on skeletal maturation and predicted adult height. Tamoxifen significantly decreased the rate of skeletal maturation and increased the predicted adult height without negative effects on sexual maturation. Additional evaluation of this therapy is now required to determine if the increase in predicted adult height results in a clinically significant increase in final adult height.

Key Words: growth • puberty

Abbreviations: SERM, selective estrogen receptor modulator • PAH, predicted adult height • TV, testicular volume • {Delta}BA, change in bone age • {Delta}CA, change in chronologic age • SDS, SD score

Accepted May 18, 2005.




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