Published online September 30, 2005
PEDIATRICS Vol. 116 No. 4 October 2005, pp. 841-843 (doi:10.1542/10.1542/peds.2004-2142)
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Measurement of Transcutaneous Hemoglobin Concentration by Noninvasive White-Light Spectroscopy in Infants

Heike Rabe, MD*, Natascha Stupp, MBBS{ddagger}, Murat Özgün, MBBS{ddagger}, Erik Harms, MD{ddagger} and Holger Jungmann, MD§

* Department of Neonatology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom
{ddagger} Department of Neonatology, Children’s University Hospital, Münster, Federal Republic of Germany
§ Department of Neonatology, Institute of Cancer Research, University of Witten/Herdecke, Herdecke, Federal Republic of Germany

Objective. To compare transcutaneously spectroscopically measured hemoglobin values with venous hemoglobin values in infants.

Study Design. Prospective study in healthy preterm and term infants who were breathing spontaneously.

Results. Recordings were obtained from 85 stable infants (median gestational age at measurement: 36 weeks [range: 34–43 weeks]; median body weight: 1890 g [range: 1095–4360 g]). The spectroscopic hemoglobin values were corrected for inhomogeneous distribution of hemoglobin in the tissue. The venous and spectroscopic hemoglobin values were then compared by using the Bland-Altman method, which gave an error of <5%.

Conclusions. This pilot study could illustrate a good relation between the 2 methods for measuring hemoglobin. Larger studies are required to validate the spectroscopic method in those with conditions that affect the skin microcirculation (eg, septicemia).

Key Words: skin microcirculation • phlebotomy • iatrogenic blood loss • noninvasive method • neonate

Accepted Jan 6, 2005.


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