Published online July 1, 2005
PEDIATRICS Vol. 116 No. 2 August 2005, pp. e221-e228 (doi:10.1542/peds.2004-2334)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sarker, S. A.
Right arrow Articles by Hammarström, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sarker, S. A.
Right arrow Articles by Hammarström, L.
Related Collections
Right arrow Infectious Disease & Immunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

ELECTRONIC ARTICLE

Lactobacillus paracasei Strain ST11 Has No Effect on Rotavirus but Ameliorates the Outcome of Nonrotavirus Diarrhea in Children From Bangladesh

Shafiqul A. Sarker, MD*, Shamima Sultana, MBBS*, George J. Fuchs, MD*,{ddagger}, Nur H. Alam, MD*, Tasnim Azim, MBBS, PhD*, Harald Brüssow, PhD§ and Lennart Hammarström, MD, PhD||

* International Centre for Diarrheal Disease Research, Centre for Health and Population Research, Dhaka, Bangladesh
{ddagger} University of Arkansas for Medical Sciences, Little Rock, Arkansas
§ Nestlé Research Centre, Lausanne, Switzerland
|| Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden

Background. Previous studies have shown that selected strains of lactobacilli that are administered orally result in a modest reduction of diarrhea duration. However, duration alone is not considered optimal for therapeutic evaluation of any agent in diarrhea.

Objective. To examine the effect of a new probiotic, Lactobacillus paracasei strain ST11 (ST11), in acute childhood diarrhea by using evaluation criteria recommended by the World Health Organization.

Methods. In a randomized, double-blind, placebo-controlled clinical trial, 230 male infants and young children, 4 to 24 months of age, presenting with diarrhea of <2 days' duration were admitted to the metabolic research ward of the International Centre for Diarrheal Disease Research, Bangladesh, and fed 1010 colony-forming units of lyophilized ST11 or placebo daily for 5 days. Stool output and frequency, oral rehydration solution intake, and excretion of rotavirus were monitored daily.

Results. No effect of ST11 treatment on severe rotavirus diarrhea was observed. However, the probiotic treatment did significantly reduce cumulative stool output (225 ± 218 vs 381 ± 240 mL/kg), stool frequency (27.9 ± 17 vs 42.5 ± 26), and oral rehydration solution intake (180 ± 207 vs 331 ± 236 mL/kg) in children with less-severe nonrotavirus diarrhea compared with those receiving placebo treatment. A significantly higher proportion of nonrotavirus children receiving ST11 had their diarrhea resolve within 6 days of therapy (ST11 versus placebo: 76% vs 49%).

Conclusions. ST11 has a clinically significant benefit in the management of children with nonrotavirus-induced diarrhea, but it is ineffective in those with rotavirus diarrhea.

Key Words: children • diarrhea • rotavirus • lactobacillus • probiotic

Abbreviations: ST11, Lactobacillus paracasei strain ST11 • ICDDR,B, International Centre for Diarrheal Disease Research, Bangladesh • ORS, oral rehydration solution • ELISA, enzyme-linked immunosorbent assay

Accepted Feb 14, 2005.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
S.-T. T. Li, E. J. Klein, P. I. Tarr, and D. M. Denno
Parental Management of Childhood Diarrhea
Clinical Pediatrics, April 1, 2009; 48(3): 295 - 303.
[Abstract] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. P. Chouraqui, D. Grathwohl, J. M. Labaune, J. M. Hascoet, I. de Montgolfier, M. Leclaire, M. Giarre, and P. Steenhout
Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial
Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1365 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. S. Frick, K. Fink, F. Kahl, M. J. Niemiec, M. Quitadamo, K. Schenk, and I. B. Autenrieth
Identification of Commensal Bacterial Strains That Modulate Yersinia enterocolitica and Dextran Sodium Sulfate-Induced Inflammatory Responses: Implications for the Development of Probiotics
Infect. Immun., July 1, 2007; 75(7): 3490 - 3497.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
J. M. Saavedra
Use of Probiotics in Pediatrics: Rationale, Mechanisms of Action, and Practical Aspects
Nutr Clin Pract, June 1, 2007; 22(3): 351 - 365.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
B. Berger, R. D. Pridmore, C. Barretto, F. Delmas-Julien, K. Schreiber, F. Arigoni, and H. Brussow
Similarity and Differences in the Lactobacillus acidophilus Group Identified by Polyphasic Analysis and Comparative Genomics
J. Bacteriol., February 15, 2007; 189(4): 1311 - 1321.
[Abstract] [Full Text] [PDF]