Published online March 1, 2005
PEDIATRICS Vol. 115 No. 3 March 2005, pp. 662-666 (doi:10.1542/10.1542/peds.2004-0820)
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Home Use of the GlucoWatch G2 Biographer in Children With Diabetes

Eba Hathout, MD*, Nina Patel, MD*, Christina Southern, MD*, Julie Hill, RN*, Reginald Anderson, MA*, Jeannine Sharkey, CDE*, Merrilee Hadley-Scofield, RD*, Long Tran, MA*, Amy Leptien, BA{ddagger}, Margarita Lopatin, MS{ddagger}, Betty Wang, MS{ddagger}, John Mace, MD* and Richard Eastman, MD{ddagger}

* Pediatric Diabetes Center, Loma Linda University, Loma Linda, California
{ddagger} Cygnus Inc, Redwood City, California

Objective. To evaluate usability, accuracy, and hypoglycemia detection of the GlucoWatch G2 Biographer (GW2B) in children aged 1 to 17 years.

Methods. After a 15-hour study of device accuracy, 46 children (15 <7 years, 31 ≥7 years) with type 1 diabetes were enrolled for an extended-wear outcome study: 2 daytime and 2 nighttime 15-hr wear periods each week and blood glucose monitoring 4 times daily for 3 months.

Results. A total of 531 paired GW2B/meter readings were available for accuracy assessment. The correlation coefficients were 0.58 and 0.74 (ages <7 and ≥7 years, respectively). There was no significant change in hemoglobin A1C or weight-adjusted insulin dose at 3 months after biographer use. Forty-two episodes of hypoglycemia were detected by the GW2B, 33 of which were confirmed by blood glucose meters. Sensitivity and specificity of audible low-glucose alerts were ~79% and 83%, respectively. No significant side effects were reported.

Conclusion. The GW2B is usable and safe in children who are <7 years or older in the home setting. The GW2B can detect asymptomatic nocturnal hypoglycemia in younger children.

Key Words: continuous glucose monitoring • noninvasive glucose monitoring • pediatric diabetes

Abbreviations: GW2B, GlucoWatch G2 Automatic Glucose Biographer • HbA1c, hemoglobin A1c

Accepted Jul 26, 2004.


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