Published online January 14, 2005
PEDIATRICS Vol. 115 No. 2 February 2005, pp. e245-e248 (doi:10.1542/peds.2004-1536)
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ELECTRONIC ARTICLE

Letrozole Significantly Improves Growth Potential in a Pubertal Boy With Growth Hormone Deficiency

Ping Zhou, MD, Bina Shah, MD, Kris Prasad, PhD and Raphael David, MD

From the Division of Pediatric Endocrinology, New York University School of Medicine, New York, New York

Clinical experience with using an aromatase inhibitor to suppress estrogen production during puberty for improvement of growth potential in adolescents with short stature is limited. This report documents treatment of such a patient with a combination of growth hormone and letrozole, a third-generation aromatase inhibitor. Our case demonstrates a favorable outcome on a short-term basis.

Key Words: bone mineral density • growth hormone • hormonal control • short stature • aromatase inhibitor

Abbreviations: AI, aromatase inhibitor • BMD, bone mineral density • GH, growth hormone • PTH, parathyroid hormone • IGF, insulin-like growth factor

Accepted Oct 21, 2004.