Published online December 15, 2004
PEDIATRICS Vol. 115 No. 1 January 2005, pp. e15-e19 (doi:10.1542/peds.2004-1152)

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ELECTRONIC ARTICLE

Frequency of Infective Endocarditis Among Infants and Children With Staphylococcus aureus Bacteremia

Anne Marie Valente, MD^*,, Rajiv Jain, MD, Mark Scheurer, MD^||, Vance G. Fowler, Jr, MD^,¶, G. Ralph Corey, MD^,¶, A. Resai Bengur, MD^#, Stephen Sanders, MD^** and Jennifer S. Li, MD^*,¶

^* Departments of Pediatrics
Medicine
^¶ Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
Department of Medicine, State University of New York, Buffalo, New York
^|| Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina
^# Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio
^** Departimento Medico Chirurgico di Cardiologia Pediatria, Ospedale Pediatrico Bambino Gesù, Rome, Italy

Purpose. The prevalence of infective endocarditis (IE) among children with Staphylococcus aureus bacteremia (SAB) is unknown. The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center.

Methods. Between July 1998 and June 2001, all children who developed SAB whose parent/guardian signed informed consent underwent echocardiography. Clinical and follow-up results were collected prospectively. Endocarditis was classified according to the modified Duke criteria.

Results. Fifty-one children developed SAB during the study interval. Definite (6 patients [11.8%]) or possible (4 patients [7.8%]) IE was present in 10 of 51 (20%) children with SAB. Most children (73%) developed bacteremia as a consequence of an infected intravascular device. Children with underlying congenital heart disease had a significantly higher prevalence of definite or possible IE, compared with those with structurally normal hearts (53% vs 3%). All patients with definite IE had multiple positive blood cultures. Mortality was high among patients with and without IE (40% vs 12%).

Conclusions. In this study, the prevalence of definite IE among children with SAB was 12% and was frequently associated with congenital heart disease and multiple positive blood cultures. The mortality for children with SAB and definite or possible S aureus IE is high.

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Key Words: infective endocarditis • Staphylococcus aureus • congenital heart disease

Abbreviations: SAB, Staphylococcus aureus bacteremia • IE, infective endocarditis • TTE, transthoracic echocardiogram • TEE, transesophageal echocardiogram

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Accepted Aug 9, 2004.

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