Published online November 15, 2004
PEDIATRICS Vol. 114 No. 6 December 2004, pp. e752-e756 (doi:10.1542/peds.2004-0485)
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ELECTRONIC ARTICLE

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

Kyung-Yil Lee, MD, Yeong-Heum Yeon, MD and Byung-Churl Lee, MD

From the Department of Pediatrics, Catholic University of Korea, College of Medicine, Seoul, Republic of Korea

We reviewed 12 patients who had Kikuchi-Fujimoto disease (KFD) and presented with prolonged fever and lymphadenopathy. The clinical and laboratory aspects of the patients confirmed by excisional lymph node biopsy were analyzed. The mean age of the children was 11.0 ± 3.0 years (range: 6–15 years). The male-to-female ratio was 1.4:1. The median duration of fever before admission and the total duration of fever was 13 days (range: 7–65 days) and 19.5 days (range: 9–75 days), respectively. One patient had supraclavicular lymphadenopathy, 10 had cervical involvement, and 1 had axillary lymphadenopathy. All of the histologic findings of the lymph node biopsies showed the characteristic findings consistent with KFD, such as paracortical necrosis with karyorrhexis and an increase in the number of phagocytic histiocytes and atypical lymphocytes. As for the laboratory findings, leukopenia (3600 ± 900 per mm3), anemia (hemoglobin 11.4 ± 1.2 g/dL), an elevated erythrocyte sedimentation rate (44 ± 18 mm/hour), and a relatively low C-reactive protein level (1.3 ± 1.1 mg/dL) were noted. Eight patients received conservative therapy with antipyretics, and 3 patients were treated with prednisolone. KFD is a rare disease yet should be considered in the differential diagnosis for older children with prolonged fever and lymphadenopathy.

Key Words: Kikuchi-Fujimoto disease • subacute necrotizing lymphadenitis • prednisolone

Abbreviations: KFD, Kikuchi-Fujimoto disease • ESR, erythrocyte sedimentation rate • CRP, C-reactive protein • LDH, lactate dehydrogenase

Accepted Jul 1, 2004.