Published online December 1, 2004
PEDIATRICS Vol. 114 No. 6 December 2004, pp. 1673-1675 (doi:10.1542/peds.2004-0491)
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EXPERIENCE AND REASON

Spectrum of Clinical Manifestations of West Nile Virus Infection in Children

Robert Yim, MD, Klara M. Posfay-Barbe, MD, Dawn Nolt, MD, MPH, George Fatula, MD and Ellen R. Wald, MD

From the Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Reports of clinical manifestations of West Nile virus (WNV) infections in children have been relatively rare. Four cases of WNV infection in children are described: the first report of prolonged encephalitis and fulminant hepatitis caused by WNV, and 3 other presentations of WNV, including the first report of ocular involvement in a child.

Key Words: West Nile virus • hepatitis • vitritis • encephalitis • meningitis • child

Abbreviations: WNV, West Nile virus • CNS, central nervous system • CBC, complete blood count • WBC, white blood cell • CSF, cerebrospinal fluid • CPK, creatine phosphokinase • HSV, herpes simplex virus • CT, computed tomography • Ig, immunoglobulin • ELISA, enzyme-linked immunosorbent assay

Accepted May 26, 2004.


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