PEDIATRICS Vol. 114 No. 3 September 2004, pp. e373-e377 (doi:10.1542/peds.2004-0196)
ELECTRONIC ARTICLE |
Blood Pressure at 6 Years of Age After Prenatal Exposure to Betamethasone: Follow-up Results of a Randomized, Controlled Trial



* Clinical Trials Research Unit
Liggins Institute, University of Auckland, Auckland, New Zealand
Starship Children's Hospital, Auckland, New Zealand
Objective. To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood.
Design. Prospective follow-up study of a randomized, double-blind, placebo-controlled trial.
Setting. National Women's Hospital (Auckland, New Zealand).
Participants. Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS.
Intervention. Mothers received 2 doses of betamethasone (12 mg) or placebo, administered through intramuscular injection, 24 hours apart.
Main Outcome Measures. Systolic and diastolic blood pressure at 6 years of age.
Results. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: 1.6 mm Hg; 95% confidence interval: 4.1 to 0.8 mm Hg; diastolic: 0.3 mm Hg; 95% confidence interval: 2.5 to 1.8 mm Hg).
Conclusion. Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age.
Key Words: prenatal glucocorticoids respiratory distress syndrome blood pressure long-term follow-up
Abbreviations: RDS, respiratory distress syndrome CI, confidence interval RCT, randomized, controlled trial
Accepted Apr 26, 2004.
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