Published online September 1, 2004
PEDIATRICS Vol. 114 No. 3 September 2004, pp. 782-785 (doi:10.1542/peds.2004-0390)
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Intussusception in Early Childhood: A Cohort Study of 1.7 Million Children

Thea Kølsen Fischer, MD, DMSc*, Kristine Bihrmann, MSc{ddagger}, Michael Perch, MD§, Anders Koch, MD, PhD{ddagger}, Jan Wohlfahrt, MSc{ddagger}, Mølbak Kåre, MD, DMSc|| and Mads Melbye, MD, DMSc{ddagger}

* Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
{ddagger} Departments of Epidemiology Research
|| Epidemiology, Statens Serum Institut
§ Department of Internal Medicine, Amager University Hospital, Copenhagen, Denmark

Objective. To describe incidence and temporal trends of intussusceptions in Danish children during 1980 to 2001.

Methods. A population-based cohort study was conducted of 1.67 million children who were younger than 5 years during 1980 to 2001 and were followed up for 6.66 million person-years. The Danish National Patient Registry was used to identify cases of intussusception in the cohort. Age-specific incidence rates were main outcome measure.

Results. A total of 1814 cases of intussusception among children who were younger than 5 years were reported from 1980 to 2001. The incidence rate remained fairly constant during 1980 to 1990 but decreased by 55% (95% confidence interval: 43%–65%) from 1990 to 2001. The reduction was most pronounced among children aged 3 to 5 months.

Conclusions. The incidence of intussusception among Danish children declined significantly during the 1990s, particularly among infants 3 to 5 months of age.

Key Words: children • incidence • intussusception • population-based studies

Abbreviations: NPR, National Patient Registry • ICD, International Classification of Diseases • CI, confidence interval

Accepted Apr 28, 2004.




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