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PEDIATRICS Vol. 114 No. 2 August 2004, pp. e267-e269

ELECTRONIC ARTICLE

Intrauterine Baclofen Exposure: A Multidisciplinary Approach

Lisa R. Moran, PharmD*, Pamela G. Almeida, NNP{ddagger}, Susan Worden, RN, IBCLC§ and Kenneth M. Huttner, MD, PhD{ddagger}

* Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts
{ddagger} Division of Newborn Medicine, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts
§ Patient Care Services, MassGeneral Hospital for Children, Boston, Massachusetts

Maternal use of the antispasmodic baclofen during pregnancy is an uncommon clinical scenario and leads to uncertainty regarding neonatal risks. We present a team-based, peripartum management plan designed for safe monitoring and minimizing the risk of neonatal withdrawal after unusual drug exposure. Incorporating the expertise of neonatology, nursing, pharmacy, neurology, and the lactation service, as well as parental input, this consensus approach was implemented in a case of maternal oral baclofen use with a successful outcome for the infant and family.

Key Words: baclofen • pregnancy • neonate • withdrawal • multidisciplinary

Abbreviations: GABA, {gamma}-aminobutyric acid • AAP, American Academy of Pediatrics

Received for publication Nov 11, 2003; Accepted Mar 10, 2004.