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PEDIATRICS Vol. 114 No. 1 July 2004, pp. 282-284

EXPERIENCE AND REASON

Virilization of Young Children After Topical Androgen Use by Their Parents

Gregory J. Kunz, MD*, Karen O. Klein, MD*, Robert D. Clemons, MD{ddagger}, Michael E. Gottschalk, MD, PhD* and Kenneth Lee Jones, MD*

* Department of Pediatrics, Division of Pediatric Endocrinology, University of California, San Diego, California, and Children’s Hospital and Health Care Center, San Diego, California
{ddagger} Kaiser Permanente, Pediatric Endocrinology, San Diego, California

Children were virilized by contact with adults using cutaneous steroid preparations. Parents were unaware of the dangers of passive transfer. Laboratory data were consistent with exogenous androgen exposure. Each child had opportunity for passive exposure, and discontinuation of contact resulted in a decrease of androgen levels or regression of symptoms.

Key Words: precocious puberty • pubic hair • adrenarche • anabolic steroids

Abbreviations: 17-OHP, 17-hydroxyprogesterone • LH, luteinizing hormone • FSH, follicle-stimulating hormone • DHEA-S, dehydroepiandrosterone-sulfate

Received for publication Mar 17, 2003; Accepted Feb 2, 2004.