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PEDIATRICS Vol. 114 No. 1 July 2004, pp. 229-233

SPECIAL ARTICLE

Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: National Institute of Child Health and Human Development Conference Executive Summary

Lillian R. Blackmon, MD*, Avroy A. Fanaroff, MD{ddagger} and Tonse N. K. Raju, MD, DCH§

* University of Maryland School of Medicine, Baltimore, Maryland, USA
{ddagger} Case Western Reserve University School of Medicine and Rainbow Babies and Children’s Hospital, Cleveland, Ohio, USA
§ National Institute of Child Health and Human Development, Bethesda, Maryland, USA

In July 2003, the National Institute of Child Health and Human Development convened a conference, "Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: Bench-to-Bedside." This article will provide a summary of presentations and discussions from this conference. The summary will focus on the identified knowledge gaps in 5 areas related to bilirubin-induced brain injury and kernicterus: 1) neurobiology and neuroimaging; 2) epidemiology and issues of clinical management; 3) methodologies for assessing clinical jaundice and direct and noninvasive measurement of serum bilirubin and hemolysis; 4) therapies for management of neonatal hyperbilirubinemia; and 5) public health surveillance and systems-based approaches to prevention.

Key Words: bilirubin • kernicterus • jaundice • brain injury • infant • cerebral palsy • chorioathetosis

Abbreviations: MRI, magnetic resonance imaging

Received for publication Jan 28, 2004; Accepted Feb 3, 2004.


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